CD4+ T Cell Regulatory Network Underlies the Decrease in Th1 and the Increase in Anergic and Th17 Subsets in Severe COVID-19

In this model we use a dynamic and multistable Boolean regulatory network to provide a mechanistic explanation of the lymphopenia and dysregulation of CD4+ T cell subsets in COVID-19 and provide therapeutic targets. Using a previous model, the cytokine micro-environments found in mild, moderate, and...

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Detalles Bibliográficos
Autores principales: Martinez-Sánchez, Mariana Esther, Choreño-Parra, José Alberto, Álvarez-Buylla, Elena R., Zúñiga, Joaquín, Balderas-Martínez, Yalbi Itzel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865341/
https://www.ncbi.nlm.nih.gov/pubmed/36678366
http://dx.doi.org/10.3390/pathogens12010018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865341/
https://www.ncbi.nlm.nih.gov/pubmed/36678366
http://dx.doi.org/10.3390/pathogens12010018

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