Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A-Rearranged Acute B-Lymphoblastic Leukemia Cells

Numerous hematologic neoplasms, including acute B-lymphoblastic leukemia (B-ALL), are characterized by overexpression of anti-apoptotic BCL-2 family proteins. Despite the high clinical efficacy of the specific BCL-2 inhibitor venetoclax in acute myeloid leukemia (AML) and chronic lymphocytic leukemi...

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Detalles Bibliográficos
Autores principales: Holz, Clemens, Lange, Sandra, Sekora, Anett, Knuebel, Gudrun, Krohn, Saskia, Murua Escobar, Hugo, Junghanss, Christian, Richter, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865387/
https://www.ncbi.nlm.nih.gov/pubmed/36674872
http://dx.doi.org/10.3390/ijms24021359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865387/
https://www.ncbi.nlm.nih.gov/pubmed/36674872
http://dx.doi.org/10.3390/ijms24021359

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