In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance

This study aimed to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy that enables the composite electrolytes to create a coating with be...

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Autores principales: Jian, Shun-Yi, Lin, Chiu-Feng, Tsai, Tung-Lin, Wang, Pei-Hua, Chen, Chung-Hwan, Lin, Sung-Yen, Tseng, Chun-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865414/
https://www.ncbi.nlm.nih.gov/pubmed/36675115
http://dx.doi.org/10.3390/ijms24021602
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author Jian, Shun-Yi
Lin, Chiu-Feng
Tsai, Tung-Lin
Wang, Pei-Hua
Chen, Chung-Hwan
Lin, Sung-Yen
Tseng, Chun-Chieh
author_facet Jian, Shun-Yi
Lin, Chiu-Feng
Tsai, Tung-Lin
Wang, Pei-Hua
Chen, Chung-Hwan
Lin, Sung-Yen
Tseng, Chun-Chieh
author_sort Jian, Shun-Yi
collection PubMed
description This study aimed to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy that enables the composite electrolytes to create a coating with better corrosion resistance and solve the problems of uneven and excessive degradation. A magnesium alloy bone screw made in this way was able to promote the bone healing reaction after implantation in rabbits. Additionally, it was found that the MAO-treated samples could be sustained in simulated body-fluid solution, exhibiting excellent corrosion resistance and electrochemical stability. The Ca ions deposited in the MAO coating were not cytotoxic and were beneficial in enhancing bone healing after implantation.
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spelling pubmed-98654142023-01-22 In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance Jian, Shun-Yi Lin, Chiu-Feng Tsai, Tung-Lin Wang, Pei-Hua Chen, Chung-Hwan Lin, Sung-Yen Tseng, Chun-Chieh Int J Mol Sci Article This study aimed to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy that enables the composite electrolytes to create a coating with better corrosion resistance and solve the problems of uneven and excessive degradation. A magnesium alloy bone screw made in this way was able to promote the bone healing reaction after implantation in rabbits. Additionally, it was found that the MAO-treated samples could be sustained in simulated body-fluid solution, exhibiting excellent corrosion resistance and electrochemical stability. The Ca ions deposited in the MAO coating were not cytotoxic and were beneficial in enhancing bone healing after implantation. MDPI 2023-01-13 /pmc/articles/PMC9865414/ /pubmed/36675115 http://dx.doi.org/10.3390/ijms24021602 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jian, Shun-Yi
Lin, Chiu-Feng
Tsai, Tung-Lin
Wang, Pei-Hua
Chen, Chung-Hwan
Lin, Sung-Yen
Tseng, Chun-Chieh
In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title_full In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title_fullStr In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title_full_unstemmed In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title_short In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance
title_sort in vivo degradation behavior of magnesium alloy for bone implants with improving biological activity, mechanical properties, and corrosion resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865414/
https://www.ncbi.nlm.nih.gov/pubmed/36675115
http://dx.doi.org/10.3390/ijms24021602
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