Cargando…

What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond

Cryptococcus species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by Cryptococcus neoformans, Cryptococcus gattii, a genotypically and phenotypically distinct species, is responsible for 11–33% of global cases of crypto...

Descripción completa

Detalles Bibliográficos
Autores principales: Beardsley, Justin, Dao, Aiken, Keighley, Caitlin, Garnham, Katherine, Halliday, Catriona, Chen, Sharon C.-A., Sorrell, Tania C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865494/
https://www.ncbi.nlm.nih.gov/pubmed/36675862
http://dx.doi.org/10.3390/jof9010041
_version_ 1784875852034473984
author Beardsley, Justin
Dao, Aiken
Keighley, Caitlin
Garnham, Katherine
Halliday, Catriona
Chen, Sharon C.-A.
Sorrell, Tania C.
author_facet Beardsley, Justin
Dao, Aiken
Keighley, Caitlin
Garnham, Katherine
Halliday, Catriona
Chen, Sharon C.-A.
Sorrell, Tania C.
author_sort Beardsley, Justin
collection PubMed
description Cryptococcus species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by Cryptococcus neoformans, Cryptococcus gattii, a genotypically and phenotypically distinct species, is responsible for 11–33% of global cases of cryptococcosis. Despite best treatment, C. gattii infections are associated with early mortality rates of 10–25%. The World Health Organization’s recently released Fungal Priority Pathogen List classified C. gattii as a medium-priority pathogen due to the lack of effective therapies and robust clinical and epidemiological data. This narrative review summarizes the latest research on the taxonomy, epidemiology, pathogenesis, laboratory testing, and management of C. gattii infections.
format Online
Article
Text
id pubmed-9865494
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98654942023-01-22 What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond Beardsley, Justin Dao, Aiken Keighley, Caitlin Garnham, Katherine Halliday, Catriona Chen, Sharon C.-A. Sorrell, Tania C. J Fungi (Basel) Review Cryptococcus species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by Cryptococcus neoformans, Cryptococcus gattii, a genotypically and phenotypically distinct species, is responsible for 11–33% of global cases of cryptococcosis. Despite best treatment, C. gattii infections are associated with early mortality rates of 10–25%. The World Health Organization’s recently released Fungal Priority Pathogen List classified C. gattii as a medium-priority pathogen due to the lack of effective therapies and robust clinical and epidemiological data. This narrative review summarizes the latest research on the taxonomy, epidemiology, pathogenesis, laboratory testing, and management of C. gattii infections. MDPI 2022-12-27 /pmc/articles/PMC9865494/ /pubmed/36675862 http://dx.doi.org/10.3390/jof9010041 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Beardsley, Justin
Dao, Aiken
Keighley, Caitlin
Garnham, Katherine
Halliday, Catriona
Chen, Sharon C.-A.
Sorrell, Tania C.
What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title_full What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title_fullStr What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title_full_unstemmed What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title_short What’s New in Cryptococcus gattii: From Bench to Bedside and Beyond
title_sort what’s new in cryptococcus gattii: from bench to bedside and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865494/
https://www.ncbi.nlm.nih.gov/pubmed/36675862
http://dx.doi.org/10.3390/jof9010041
work_keys_str_mv AT beardsleyjustin whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT daoaiken whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT keighleycaitlin whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT garnhamkatherine whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT hallidaycatriona whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT chensharonca whatsnewincryptococcusgattiifrombenchtobedsideandbeyond
AT sorrelltaniac whatsnewincryptococcusgattiifrombenchtobedsideandbeyond