Cargando…

Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation. Neurodegeneratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Rojas-García, Alejandro, Fernández-Ochoa, Álvaro, Cádiz-Gurrea, María de la Luz, Arráez-Román, David, Segura-Carretero, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865516/
https://www.ncbi.nlm.nih.gov/pubmed/36678322
http://dx.doi.org/10.3390/nu15020449
_version_ 1784875857732435968
author Rojas-García, Alejandro
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Arráez-Román, David
Segura-Carretero, Antonio
author_facet Rojas-García, Alejandro
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Arráez-Román, David
Segura-Carretero, Antonio
author_sort Rojas-García, Alejandro
collection PubMed
description Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation. Neurodegeneration affects millions of people worldwide, and no integral cure has been created yet. Here, bioactive compounds have been proven to exert numerous beneficial effects due to their remarkable bioactivity, so they could be considered as great options for the development of new neuroprotective strategies. Phenolic bioactives have been reported to be found in edible part of plants; however, over the last years, a large amount of research has focused on the phenolic richness that plant by-products possess, which sometimes even exceeds the content in the pulp. Thus, their possible application as an emergent neuroprotective technique could also be considered as an optimal strategy to revalorize these agricultural residues (those originated from plant processing). This review aims to summarize main triggers of neurodegeneration, revise the state of the art in plant extracts and their role in avoiding neurodegeneration and discuss how their main phenolic compounds could exert their neuroprotective effects. For this purpose, a diverse search of studies has been conducted, gathering a large number of papers where by-products were used as strong sources of phenolic compounds for their neuroprotective properties. Finally, although a lack of investigation is quite remarkable and greatly limits the use of these compounds, phenolics remain attractive for research into new multifactorial anti-neurodegenerative nutraceuticals.
format Online
Article
Text
id pubmed-9865516
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98655162023-01-22 Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds Rojas-García, Alejandro Fernández-Ochoa, Álvaro Cádiz-Gurrea, María de la Luz Arráez-Román, David Segura-Carretero, Antonio Nutrients Review Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation. Neurodegeneration affects millions of people worldwide, and no integral cure has been created yet. Here, bioactive compounds have been proven to exert numerous beneficial effects due to their remarkable bioactivity, so they could be considered as great options for the development of new neuroprotective strategies. Phenolic bioactives have been reported to be found in edible part of plants; however, over the last years, a large amount of research has focused on the phenolic richness that plant by-products possess, which sometimes even exceeds the content in the pulp. Thus, their possible application as an emergent neuroprotective technique could also be considered as an optimal strategy to revalorize these agricultural residues (those originated from plant processing). This review aims to summarize main triggers of neurodegeneration, revise the state of the art in plant extracts and their role in avoiding neurodegeneration and discuss how their main phenolic compounds could exert their neuroprotective effects. For this purpose, a diverse search of studies has been conducted, gathering a large number of papers where by-products were used as strong sources of phenolic compounds for their neuroprotective properties. Finally, although a lack of investigation is quite remarkable and greatly limits the use of these compounds, phenolics remain attractive for research into new multifactorial anti-neurodegenerative nutraceuticals. MDPI 2023-01-14 /pmc/articles/PMC9865516/ /pubmed/36678322 http://dx.doi.org/10.3390/nu15020449 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rojas-García, Alejandro
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Arráez-Román, David
Segura-Carretero, Antonio
Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title_full Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title_fullStr Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title_full_unstemmed Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title_short Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds
title_sort neuroprotective effects of agri-food by-products rich in phenolic compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865516/
https://www.ncbi.nlm.nih.gov/pubmed/36678322
http://dx.doi.org/10.3390/nu15020449
work_keys_str_mv AT rojasgarciaalejandro neuroprotectiveeffectsofagrifoodbyproductsrichinphenoliccompounds
AT fernandezochoaalvaro neuroprotectiveeffectsofagrifoodbyproductsrichinphenoliccompounds
AT cadizgurreamariadelaluz neuroprotectiveeffectsofagrifoodbyproductsrichinphenoliccompounds
AT arraezromandavid neuroprotectiveeffectsofagrifoodbyproductsrichinphenoliccompounds
AT seguracarreteroantonio neuroprotectiveeffectsofagrifoodbyproductsrichinphenoliccompounds