Cargando…

Inhibitory Effects of 2-Aminoethoxydiphenyl Borate (2-APB) on Three K(V)1 Channel Currents

2-Aminoethoxydiphenyl borate (2-APB), a boron-containing compound, is a multitarget compound with potential as a drug precursor and exerts various effects in systems of the human body. Ion channels are among the reported targets of 2-APB. The effects of 2-APB on voltage-gated potassium channels (K(V...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Wei, Pan, Lanying, Stalin, Antony, Xu, Jianwei, Wu, Liren, Ke, Xianfu, Chen, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865587/ https://www.ncbi.nlm.nih.gov/pubmed/36677928 http://dx.doi.org/10.3390/molecules28020871

Ejemplares similares

2-Aminoethoxydiphenyl-borate reduces arsenic-induced cardiotoxicity in rats: Effect of 2-APB on arsenic-induced cardiotoxicity
por: Qin, Wenjuan, et al.
Publicado: (2022)

Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels
por: Hamaguchi, Yukihisa, et al.
Publicado: (2008)

2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1
por: Xu, Xiaolan, et al.
Publicado: (2016)

Activation of rat transient receptor potential cation channel subfamily V member 1 channels by 2-aminoethoxydiphenyl borate
por: Mamatova, Knara Nazaralievna, et al.
Publicado: (2013)

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations
por: Fernández-Serra, Rocío, et al.
Publicado: (2022)

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice
por: Morihara, Hirofumi, et al.
Publicado: (2017)

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)
por: Beltrán, Leopoldo, et al.
Publicado: (2013)

Expression of Concern: 2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice
Publicado: (2023)

The 2-aminoethoxydiphenyl borate analog, DPB161 blocks store-operated Ca(2+) entry in acutely dissociated rat submandibular cells
por: Xia, Kunkun, et al.
Publicado: (2017)

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
por: Gochman, Aaron, et al.
Publicado: (2023)

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB
por: Singh, Appu K., et al.
Publicado: (2018)

Selective potentiation of 2-APB-induced activation of TRPV1–3 channels by acid
por: Gao, Luna, et al.
Publicado: (2016)

2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm
por: Lefièvre, Linda, et al.
Publicado: (2012)

Modulation of activation and inactivation by Ca(2+) and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis
por: Kühn, Frank J. P., et al.
Publicado: (2017)

Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel
por: Zhao, Wei, et al.
Publicado: (2019)

2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels
por: Neumann-Raizel, Hagit, et al.
Publicado: (2019)

The calcium channel modulator 2-APB hydrolyzes in physiological buffers and acts as an effective radical scavenger and inhibitor of the NADPH oxidase 2
por: Slowik, Ewa Jasmin, et al.
Publicado: (2023)

The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites
por: Wang, Jintao, et al.
Publicado: (2023)

Drofenine: a 2-APB analog with improved selectivity for human TRPV3
por: Deering-Rice, Cassandra E, et al.
Publicado: (2014)

2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets
por: Wei, Hao, et al.
Publicado: (2020)

Kinetic characterization of Vibrio cholerae ApbE: Substrate specificity and regulatory mechanisms
por: Fang, Xuan, et al.
Publicado: (2017)

Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium
por: Hossain, Md Reduanul, et al.
Publicado: (2022)

Detection and quantification of glycosylated queuosine modified tRNAs by acid denaturing and APB gels
por: Zhang, Wen, et al.
Publicado: (2020)

State-dependent block of Orai3 TM1 and TM3 cysteine mutants: Insights into 2-APB activation
por: Amcheslavsky, Anna, et al.
Publicado: (2014)

A-Site Cation Dependence of Self-Healing in Polycrystalline APbI(3) Perovskite Films
por: Singh, Pallavi, et al.
Publicado: (2023)

Polarized localization and borate-dependent degradation of the Arabidopsis borate transporter BOR1 in tobacco BY-2 cells
por: Yamauchi, Noboru, et al.
Publicado: (2013)

2-Cyanoanilinium tetrafluoroborate
por: Zhang, Yi
Publicado: (2009)

Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2-APB
por: Touchberry, Chad D, et al.
Publicado: (2014)

The Strength of hERG Inhibition by Erythromycin at Different Temperatures Might Be Due to Its Interacting Features with the Channels
por: Cheng, Dongrong, et al.
Publicado: (2023)

Lithium bis(2-methyllactato)borate monohydrate
por: Allen, Joshua L., et al.
Publicado: (2012)

Expanding the chemistry of borates with functional [BO(2)](−) anions
por: Huang, Chunmei, et al.
Publicado: (2021)

Characterization of ApB73, a virulence factor important for colonization of Zea mays by the smut Ustilago maydis
por: Stirnberg, Alexandra, et al.
Publicado: (2016)

Potassium pentaborate
por: Wu, Qi
Publicado: (2011)

Zinc Borate Hydrolysis
por: Schubert, David M.
Publicado: (2022)

Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells
por: Schild, Achille, et al.
Publicado: (2020)

A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages
por: Wu, Ching-Ying, et al.
Publicado: (2016)

Molecular insights into the enzymatic diversity of flavin‐trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm
por: Deka, Ranjit K., et al.
Publicado: (2015)

Switchable Anion Exchange in Polymer-Encapsulated APbX(3) Nanocrystals Delivers Stable All-Perovskite White Emitters
por: Imran, Muhammad, et al.
Publicado: (2021)

Antibacterial Effects of Sodium Borate and Calcium Borate Based Polymeric Coatings for Orthopedic Implants
por: Coskun, Huseyin S, et al.
Publicado: (2022)

1-(2-Ureidoethyl)quinolinium tetraphenylborate
por: Dong, Zhi-Yun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bf91il3jn6ukhshmrca5flpisj