mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells

Hypoxia is a critical condition that governs survival, self-renewal, quiescence, metabolic shift and refractoriness to leukemic stem cell (LSC) therapy. The present study aims to investigate the hypoxia-driven regulation of the mammalian Target of the Rapamycin-2 (mTORC2) complex to unravel it as a...

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Detalles Bibliográficos
Autores principales: Panuzzo, Cristina, Pironi, Lucrezia, Maglione, Alessandro, Rocco, Simone, Stanga, Serena, Riganti, Chiara, Kopecka, Joanna, Ali, Muhammad Shahzad, Pergolizzi, Barbara, Bracco, Enrico, Cilloni, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865638/
https://www.ncbi.nlm.nih.gov/pubmed/36674750
http://dx.doi.org/10.3390/ijms24021234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865638/
https://www.ncbi.nlm.nih.gov/pubmed/36674750
http://dx.doi.org/10.3390/ijms24021234

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