Cargando…

Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report

Diarrheal disease continues to be a leading cause of death in children under five years old in developing countries, where it is responsible for the death of approximately half a million children each year. Establishing the cause of diarrheal disease can be difficult in developing areas due to the l...

Descripción completa

Detalles Bibliográficos
Autores principales: Dal Canto, Giulia, Artaiga, Tawaddud Hassan Eisa, Mohamed, Abdulrahman Ibrahiem, Hassan, Hayat Amin Makki, Adam, Doaa Mahmoud, Ahmed, Moram Awadalla Ibrahiem, Motwali, Jihad, Valenti, Manuela, Esposito, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865698/
https://www.ncbi.nlm.nih.gov/pubmed/36677457
http://dx.doi.org/10.3390/microorganisms11010165
_version_ 1784875903170379776
author Dal Canto, Giulia
Artaiga, Tawaddud Hassan Eisa
Mohamed, Abdulrahman Ibrahiem
Hassan, Hayat Amin Makki
Adam, Doaa Mahmoud
Ahmed, Moram Awadalla Ibrahiem
Motwali, Jihad
Valenti, Manuela
Esposito, Susanna
author_facet Dal Canto, Giulia
Artaiga, Tawaddud Hassan Eisa
Mohamed, Abdulrahman Ibrahiem
Hassan, Hayat Amin Makki
Adam, Doaa Mahmoud
Ahmed, Moram Awadalla Ibrahiem
Motwali, Jihad
Valenti, Manuela
Esposito, Susanna
author_sort Dal Canto, Giulia
collection PubMed
description Diarrheal disease continues to be a leading cause of death in children under five years old in developing countries, where it is responsible for the death of approximately half a million children each year. Establishing the cause of diarrheal disease can be difficult in developing areas due to the lack of diagnostic tests, and thus empirical therapies are often required. In these settings, the choice of antibiotic (or the choice to not give it) depends on suspected agents, host conditions and local epidemiology. Herein, we report a representative case of a ten-month-old male patient with severe acute malnutrition (SAM) admitted to the Emergency Paediatric Clinic in Port Sudan for amoebic dysentery complicated by hypovolemic shock and sepsis, treated by target therapy for Entamoeba histolytica infection associated with empiric antibiotic therapy. Due to the absence of clinical improvement, Ciprofloxacin was added to the first-line treatment. This case highlights that in low-income countries amoebiasis, especially in children with SAM, may result in life-threatening complications. Although stool microscopy remains the most used diagnostic test in these settings, a novel inexpensive, easy to use and rapid diagnostic test would be warranted to reach a microbiological diagnosis and guide clinical decision. Further studies will be necessary to identify the patterns of antimicrobial resistance in order to appropriately manage these complicated cases.
format Online
Article
Text
id pubmed-9865698
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98656982023-01-22 Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report Dal Canto, Giulia Artaiga, Tawaddud Hassan Eisa Mohamed, Abdulrahman Ibrahiem Hassan, Hayat Amin Makki Adam, Doaa Mahmoud Ahmed, Moram Awadalla Ibrahiem Motwali, Jihad Valenti, Manuela Esposito, Susanna Microorganisms Case Report Diarrheal disease continues to be a leading cause of death in children under five years old in developing countries, where it is responsible for the death of approximately half a million children each year. Establishing the cause of diarrheal disease can be difficult in developing areas due to the lack of diagnostic tests, and thus empirical therapies are often required. In these settings, the choice of antibiotic (or the choice to not give it) depends on suspected agents, host conditions and local epidemiology. Herein, we report a representative case of a ten-month-old male patient with severe acute malnutrition (SAM) admitted to the Emergency Paediatric Clinic in Port Sudan for amoebic dysentery complicated by hypovolemic shock and sepsis, treated by target therapy for Entamoeba histolytica infection associated with empiric antibiotic therapy. Due to the absence of clinical improvement, Ciprofloxacin was added to the first-line treatment. This case highlights that in low-income countries amoebiasis, especially in children with SAM, may result in life-threatening complications. Although stool microscopy remains the most used diagnostic test in these settings, a novel inexpensive, easy to use and rapid diagnostic test would be warranted to reach a microbiological diagnosis and guide clinical decision. Further studies will be necessary to identify the patterns of antimicrobial resistance in order to appropriately manage these complicated cases. MDPI 2023-01-08 /pmc/articles/PMC9865698/ /pubmed/36677457 http://dx.doi.org/10.3390/microorganisms11010165 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Dal Canto, Giulia
Artaiga, Tawaddud Hassan Eisa
Mohamed, Abdulrahman Ibrahiem
Hassan, Hayat Amin Makki
Adam, Doaa Mahmoud
Ahmed, Moram Awadalla Ibrahiem
Motwali, Jihad
Valenti, Manuela
Esposito, Susanna
Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title_full Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title_fullStr Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title_full_unstemmed Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title_short Amoebic Dysentery Complicated by Hypovolemic Shock and Sepsis in an Infant with Severe Acute Malnutrition: A Case Report
title_sort amoebic dysentery complicated by hypovolemic shock and sepsis in an infant with severe acute malnutrition: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865698/
https://www.ncbi.nlm.nih.gov/pubmed/36677457
http://dx.doi.org/10.3390/microorganisms11010165
work_keys_str_mv AT dalcantogiulia amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT artaigatawaddudhassaneisa amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT mohamedabdulrahmanibrahiem amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT hassanhayataminmakki amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT adamdoaamahmoud amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT ahmedmoramawadallaibrahiem amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT motwalijihad amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT valentimanuela amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport
AT espositosusanna amoebicdysenterycomplicatedbyhypovolemicshockandsepsisinaninfantwithsevereacutemalnutritionacasereport