Cargando…

Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection

In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low i...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Jiapeng, Xiao, Gongli, Yang, Hongyan, Chen, Jiayu, Li, Haiou, Liu, Xingpeng, Luo, Yunhan, Li, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865792/
https://www.ncbi.nlm.nih.gov/pubmed/36678000
http://dx.doi.org/10.3390/nano13020246
_version_ 1784875927081058304
author Su, Jiapeng
Xiao, Gongli
Yang, Hongyan
Chen, Jiayu
Li, Haiou
Liu, Xingpeng
Luo, Yunhan
Li, Jianqing
author_facet Su, Jiapeng
Xiao, Gongli
Yang, Hongyan
Chen, Jiayu
Li, Haiou
Liu, Xingpeng
Luo, Yunhan
Li, Jianqing
author_sort Su, Jiapeng
collection PubMed
description In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low interference. Four channels are polished around the cylindrical fiber, and then different metal films (gold or silver) and plasmonic materials (titanium dioxide, thallium pentoxide, or graphene) are added to the sensing area of each channel. All channels detect refractive indices in the range of 1.34 to 1.42. The sensing performance of the fiber optic sensor was numerically investigated using the full vector finite element method. After the optimization of structural parameters, the maximum wavelength sensitivity of channel-1, channel-2, channel-3, and channel-4 are 49,800 nm/RIU, 49,000 nm/RIU, 35,900 nm/RIU, and 36,800 nm/RIU, respectively. We have theoretically analyzed the sensor’s capabilities for partial bio-detection and simulated its detection capability with a wavelength sensitivity of 11,500 nm/RIU for normal red blood cells and 12,200 nm/RIU for MCF-7 cancerous cells. Our proposed sensor has a novel design, can detect multiple channels simultaneously, has strong anti-interference capability and high sensitivity, and has good sensing characteristics.
format Online
Article
Text
id pubmed-9865792
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98657922023-01-22 Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection Su, Jiapeng Xiao, Gongli Yang, Hongyan Chen, Jiayu Li, Haiou Liu, Xingpeng Luo, Yunhan Li, Jianqing Nanomaterials (Basel) Article In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low interference. Four channels are polished around the cylindrical fiber, and then different metal films (gold or silver) and plasmonic materials (titanium dioxide, thallium pentoxide, or graphene) are added to the sensing area of each channel. All channels detect refractive indices in the range of 1.34 to 1.42. The sensing performance of the fiber optic sensor was numerically investigated using the full vector finite element method. After the optimization of structural parameters, the maximum wavelength sensitivity of channel-1, channel-2, channel-3, and channel-4 are 49,800 nm/RIU, 49,000 nm/RIU, 35,900 nm/RIU, and 36,800 nm/RIU, respectively. We have theoretically analyzed the sensor’s capabilities for partial bio-detection and simulated its detection capability with a wavelength sensitivity of 11,500 nm/RIU for normal red blood cells and 12,200 nm/RIU for MCF-7 cancerous cells. Our proposed sensor has a novel design, can detect multiple channels simultaneously, has strong anti-interference capability and high sensitivity, and has good sensing characteristics. MDPI 2023-01-06 /pmc/articles/PMC9865792/ /pubmed/36678000 http://dx.doi.org/10.3390/nano13020246 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Jiapeng
Xiao, Gongli
Yang, Hongyan
Chen, Jiayu
Li, Haiou
Liu, Xingpeng
Luo, Yunhan
Li, Jianqing
Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title_full Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title_fullStr Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title_full_unstemmed Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title_short Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
title_sort highly sensitive multi-channel biosensor for low-interference simultaneous detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865792/
https://www.ncbi.nlm.nih.gov/pubmed/36678000
http://dx.doi.org/10.3390/nano13020246
work_keys_str_mv AT sujiapeng highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT xiaogongli highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT yanghongyan highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT chenjiayu highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT lihaiou highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT liuxingpeng highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT luoyunhan highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection
AT lijianqing highlysensitivemultichannelbiosensorforlowinterferencesimultaneousdetection