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Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices

In the last few decades Additive Manufacturing has advanced and is becoming important for biomedical applications. In this study we look at a variety of biomedical devices including, bone implants, tooth implants, osteochondral tissue repair patches, general tissue repair patches, nerve guidance con...

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Autores principales: Gregory, David Alexander, Fricker, Annabelle T. R., Mitrev, Peter, Ray, Meghna, Asare, Emmanuel, Sim, Daniel, Larpnimitchai, Soponvit, Zhang, Zixuan, Ma, Jinge, Tetali, Santosh S. V., Roy, Ipsita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865795/
https://www.ncbi.nlm.nih.gov/pubmed/36662087
http://dx.doi.org/10.3390/jfb14010040
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author Gregory, David Alexander
Fricker, Annabelle T. R.
Mitrev, Peter
Ray, Meghna
Asare, Emmanuel
Sim, Daniel
Larpnimitchai, Soponvit
Zhang, Zixuan
Ma, Jinge
Tetali, Santosh S. V.
Roy, Ipsita
author_facet Gregory, David Alexander
Fricker, Annabelle T. R.
Mitrev, Peter
Ray, Meghna
Asare, Emmanuel
Sim, Daniel
Larpnimitchai, Soponvit
Zhang, Zixuan
Ma, Jinge
Tetali, Santosh S. V.
Roy, Ipsita
author_sort Gregory, David Alexander
collection PubMed
description In the last few decades Additive Manufacturing has advanced and is becoming important for biomedical applications. In this study we look at a variety of biomedical devices including, bone implants, tooth implants, osteochondral tissue repair patches, general tissue repair patches, nerve guidance conduits (NGCs) and coronary artery stents to which fused deposition modelling (FDM) can be applied. We have proposed CAD designs for these devices and employed a cost-effective 3D printer to fabricate proof-of-concept prototypes. We highlight issues with current CAD design and slicing and suggest optimisations of more complex designs targeted towards biomedical applications. We demonstrate the ability to print patient specific implants from real CT scans and reconstruct missing structures by means of mirroring and mesh mixing. A blend of Polyhydroxyalkanoates (PHAs), a family of biocompatible and bioresorbable natural polymers and Poly(L-lactic acid) (PLLA), a known bioresorbable medical polymer is used. Our characterisation of the PLA/PHA filament suggest that its tensile properties might be useful to applications such as stents, NGCs, and bone scaffolds. In addition to this, the proof-of-concept work for other applications shows that FDM is very useful for a large variety of other soft tissue applications, however other more elastomeric MCL-PHAs need to be used.
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spelling pubmed-98657952023-01-22 Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices Gregory, David Alexander Fricker, Annabelle T. R. Mitrev, Peter Ray, Meghna Asare, Emmanuel Sim, Daniel Larpnimitchai, Soponvit Zhang, Zixuan Ma, Jinge Tetali, Santosh S. V. Roy, Ipsita J Funct Biomater Article In the last few decades Additive Manufacturing has advanced and is becoming important for biomedical applications. In this study we look at a variety of biomedical devices including, bone implants, tooth implants, osteochondral tissue repair patches, general tissue repair patches, nerve guidance conduits (NGCs) and coronary artery stents to which fused deposition modelling (FDM) can be applied. We have proposed CAD designs for these devices and employed a cost-effective 3D printer to fabricate proof-of-concept prototypes. We highlight issues with current CAD design and slicing and suggest optimisations of more complex designs targeted towards biomedical applications. We demonstrate the ability to print patient specific implants from real CT scans and reconstruct missing structures by means of mirroring and mesh mixing. A blend of Polyhydroxyalkanoates (PHAs), a family of biocompatible and bioresorbable natural polymers and Poly(L-lactic acid) (PLLA), a known bioresorbable medical polymer is used. Our characterisation of the PLA/PHA filament suggest that its tensile properties might be useful to applications such as stents, NGCs, and bone scaffolds. In addition to this, the proof-of-concept work for other applications shows that FDM is very useful for a large variety of other soft tissue applications, however other more elastomeric MCL-PHAs need to be used. MDPI 2023-01-10 /pmc/articles/PMC9865795/ /pubmed/36662087 http://dx.doi.org/10.3390/jfb14010040 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gregory, David Alexander
Fricker, Annabelle T. R.
Mitrev, Peter
Ray, Meghna
Asare, Emmanuel
Sim, Daniel
Larpnimitchai, Soponvit
Zhang, Zixuan
Ma, Jinge
Tetali, Santosh S. V.
Roy, Ipsita
Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title_full Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title_fullStr Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title_full_unstemmed Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title_short Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices
title_sort additive manufacturing of polyhydroxyalkanoate-based blends using fused deposition modelling for the development of biomedical devices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865795/
https://www.ncbi.nlm.nih.gov/pubmed/36662087
http://dx.doi.org/10.3390/jfb14010040
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