Wearable Noninvasive Glucose Sensor Based on Cu(x)O NFs/Cu NPs Nanocomposites

Designing highly active material to fabricate a high-performance noninvasive wearable glucose sensor was of great importance for diabetes monitoring. In this work, we developed Cu(x)O nanoflakes (NFs)/Cu nanoparticles (NPs) nanocomposites to serve as the sensing materials for noninvasive sweat-based wearable glucose sensors. We involve CuCl(2) to enhance the oxidation of Cu NPs to generate Cu(2)O/CuO NFs on the surface. Due to more active sites endowed by the Cu(x)O NFs, the as-prepared sample exhibited high sensitivity (779 μA mM(−1) cm(−2)) for noninvasive wearable sweat sensing. Combined with a low detection limit (79.1 nM), high selectivity and the durability of bending and twisting, the Cu(x)O NFs/Cu NPs-based sensor can detect the glucose level change of sweat in daily life. Such a high-performance wearable sensor fabricated by a convenient method provides a facile way to design copper oxide nanomaterials for noninvasive wearable glucose sensors.