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Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3

Arap3, a dual GTPase-activating protein (GAP) for the small GTPases Arf6 and RhoA, plays key roles in regulating a wide range of biological processes, including cancer cell invasion and metastasis. It is known that Arap3 is a PI3K effector that can bind directly to PI(3,4,5)P3, and the PI(3,4,5)P3-m...

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Detalles Bibliográficos
Autores principales:	Zhang, Youjia, Ge, Liang, Xu, Li, Liu, Yongrui, Wang, Jiarong, Liu, Chongxu, Zhao, Hongxin, Xing, Lei, Wang, Junfeng, Wu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865853/ https://www.ncbi.nlm.nih.gov/pubmed/36674645 http://dx.doi.org/10.3390/ijms24021125

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