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Role of NF-κB during Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (M. tb) causes tuberculosis infection in humans worldwide, especially among immunocompromised populations and areas of the world with insufficient funding for tuberculosis treatment. Specifically, M. tb is predominantly exhibited as a latent infection, which poses a greate...

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Autores principales: Poladian, Nicole, Orujyan, Davit, Narinyan, William, Oganyan, Armani K., Navasardyan, Inesa, Velpuri, Prathosh, Chorbajian, Abraham, Venketaraman, Vishwanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865913/
https://www.ncbi.nlm.nih.gov/pubmed/36675296
http://dx.doi.org/10.3390/ijms24021772
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author Poladian, Nicole
Orujyan, Davit
Narinyan, William
Oganyan, Armani K.
Navasardyan, Inesa
Velpuri, Prathosh
Chorbajian, Abraham
Venketaraman, Vishwanath
author_facet Poladian, Nicole
Orujyan, Davit
Narinyan, William
Oganyan, Armani K.
Navasardyan, Inesa
Velpuri, Prathosh
Chorbajian, Abraham
Venketaraman, Vishwanath
author_sort Poladian, Nicole
collection PubMed
description Mycobacterium tuberculosis (M. tb) causes tuberculosis infection in humans worldwide, especially among immunocompromised populations and areas of the world with insufficient funding for tuberculosis treatment. Specifically, M. tb is predominantly exhibited as a latent infection, which poses a greater risk of reactivation for infected individuals. It has been previously shown that M. tb infection requires pro-inflammatory and anti-inflammatory mediators to manage its associated granuloma formation via tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), interferon-γ (IFN-γ), and caseum formation via IL-10, respectively. Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) has been found to play a unique mediator role in providing a pro-inflammatory response to chronic inflammatory disease processes by promoting the activation of macrophages and the release of various cytokines such as IL-1, IL-6, IL-12, and TNF-α. NF-κB’s role is especially interesting in its mechanism of assisting the immune system’s defense against M. tb, wherein NF-κB induces IL-2 receptors (IL-2R) to decrease the immune response, but has also been shown to crucially assist in keeping a granuloma and bacterial load contained. In order to understand NF-κB’s role in reducing M. tb infection, within this literature review we will discuss the dynamic interaction between M. tb and NF-κB, with a focus on the intracellular signaling pathways and the possible side effects of NF-κB inactivation on M. tb infection. Through a thorough review of these interactions, this review aims to highlight the role of NF-κB in M. tb infection for the purpose of better understanding the complex immune response to M. tb infection and to uncover further potential therapeutic methods.
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spelling pubmed-98659132023-01-22 Role of NF-κB during Mycobacterium tuberculosis Infection Poladian, Nicole Orujyan, Davit Narinyan, William Oganyan, Armani K. Navasardyan, Inesa Velpuri, Prathosh Chorbajian, Abraham Venketaraman, Vishwanath Int J Mol Sci Review Mycobacterium tuberculosis (M. tb) causes tuberculosis infection in humans worldwide, especially among immunocompromised populations and areas of the world with insufficient funding for tuberculosis treatment. Specifically, M. tb is predominantly exhibited as a latent infection, which poses a greater risk of reactivation for infected individuals. It has been previously shown that M. tb infection requires pro-inflammatory and anti-inflammatory mediators to manage its associated granuloma formation via tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), interferon-γ (IFN-γ), and caseum formation via IL-10, respectively. Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) has been found to play a unique mediator role in providing a pro-inflammatory response to chronic inflammatory disease processes by promoting the activation of macrophages and the release of various cytokines such as IL-1, IL-6, IL-12, and TNF-α. NF-κB’s role is especially interesting in its mechanism of assisting the immune system’s defense against M. tb, wherein NF-κB induces IL-2 receptors (IL-2R) to decrease the immune response, but has also been shown to crucially assist in keeping a granuloma and bacterial load contained. In order to understand NF-κB’s role in reducing M. tb infection, within this literature review we will discuss the dynamic interaction between M. tb and NF-κB, with a focus on the intracellular signaling pathways and the possible side effects of NF-κB inactivation on M. tb infection. Through a thorough review of these interactions, this review aims to highlight the role of NF-κB in M. tb infection for the purpose of better understanding the complex immune response to M. tb infection and to uncover further potential therapeutic methods. MDPI 2023-01-16 /pmc/articles/PMC9865913/ /pubmed/36675296 http://dx.doi.org/10.3390/ijms24021772 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Poladian, Nicole
Orujyan, Davit
Narinyan, William
Oganyan, Armani K.
Navasardyan, Inesa
Velpuri, Prathosh
Chorbajian, Abraham
Venketaraman, Vishwanath
Role of NF-κB during Mycobacterium tuberculosis Infection
title Role of NF-κB during Mycobacterium tuberculosis Infection
title_full Role of NF-κB during Mycobacterium tuberculosis Infection
title_fullStr Role of NF-κB during Mycobacterium tuberculosis Infection
title_full_unstemmed Role of NF-κB during Mycobacterium tuberculosis Infection
title_short Role of NF-κB during Mycobacterium tuberculosis Infection
title_sort role of nf-κb during mycobacterium tuberculosis infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865913/
https://www.ncbi.nlm.nih.gov/pubmed/36675296
http://dx.doi.org/10.3390/ijms24021772
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