Cargando…

Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells

Acute myeloid leukemia (AML) with a nucleophosmin 1 (NPM1) mutation is a unique subtype of adult leukemia. Recent studies show that NPM1-mutated AML has high autophagy activity. However, the mechanism for upholding the high autophagic level is still not fully elucidated. In this study, we first iden...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Junpeng, Sun, Minghui, Tao, Yonghong, Ren, Jun, Peng, Meixi, Jing, Yipei, Xiao, Qiaoling, Yang, Jing, Lin, Can, Lei, Li, Yang, Zailin, Zhang, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865930/ https://www.ncbi.nlm.nih.gov/pubmed/36675134 http://dx.doi.org/10.3390/ijms24021624

Ejemplares similares

Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis
por: Xiao, Qiaoling, et al.
Publicado: (2022)

Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
por: Jing, Yipei, et al.
Publicado: (2021)

Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia
por: Peng, Meixi, et al.
Publicado: (2021)

Targeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia
por: Ren, Jun, et al.
Publicado: (2022)

Circulating plasma exosomal long non-coding RNAs LINC00265, LINC00467, UCA1, and SNHG1 as biomarkers for diagnosis and treatment monitoring of acute myeloid leukemia
por: Xiao, Qiaoling, et al.
Publicado: (2022)

DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
por: Sancho, Ana, et al.
Publicado: (2012)

Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53
por: Bonacci, Thomas, et al.
Publicado: (2014)

Correction: DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
por: Sancho, Ana, et al.
Publicado: (2012)

Correction: DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
por: Sancho, Ana, et al.
Publicado: (2012)

Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion
por: Yang, Liyuan, et al.
Publicado: (2019)

Targeting the RNA demethylase FTO for cancer therapy
por: Zhou, Lin-Lin, et al.
Publicado: (2021)

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia
por: Jin, Hongjun, et al.
Publicado: (2018)

TP53INP2 Promotes Bovine Adipocytes Differentiation Through Autophagy Activation
por: Zhang, Weiyi, et al.
Publicado: (2019)

Integrative Analysis of TP53INP2 in Head and Neck Squamous Cell Carcinoma
por: Cao, Ruoyan, et al.
Publicado: (2021)

Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia
por: Wang, Lu, et al.
Publicado: (2019)

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1
por: Seillier, Marion, et al.
Publicado: (2015)

TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells
por: Sándor, Nikolett, et al.
Publicado: (2015)

miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis
por: Xia, Xiaohuan, et al.
Publicado: (2019)

Paclitaxel Induce Apoptosis of Giant Cells Tumor of Bone via TP53INP1 Signaling
por: Xiao, Wei‐Yuan, et al.
Publicado: (2018)

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition
por: Dinh, Emilie, et al.
Publicado: (2021)

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer
por: Yu, San-Jian, et al.
Publicado: (2018)

Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer
por: Qin, Bo, et al.
Publicado: (2022)

AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response
por: Holoubek, Aleš, et al.
Publicado: (2021)

TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
por: Wang, Yi, et al.
Publicado: (2018)

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein
por: Pianigiani, Giulia, et al.
Publicado: (2022)

Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells
por: Li, Bin, et al.
Publicado: (2023)

LncRNA GAS5-mediated miR-1323 promotes tumor progression by targeting TP53INP1 in hepatocellular carcinoma
por: Zhang, Fengjuan, et al.
Publicado: (2019)

TP53INP2 Contributes to TGF-β2-Induced Autophagy during the Epithelial–Mesenchymal Transition in Posterior Capsular Opacification Development
por: Cui, Yilei, et al.
Publicado: (2022)

MiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1
por: Li, Ning, et al.
Publicado: (2019)

The biology of FTO: from nucleic acid demethylase to amino acid sensor
por: Gulati, Pawan, et al.
Publicado: (2013)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

m6A demethylase FTO and osteoporosis: potential therapeutic interventions
por: Huang, Mei, et al.
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells
por: Zou, Qin, et al.
Publicado: (2017)

MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis
por: Han, Lei, et al.
Publicado: (2021)

Downregulation of miR-3934-5p enhances A549 cell sensitivity to cisplatin by targeting TP53INP1
por: Ren, Aijun, et al.
Publicado: (2019)

miR-96 regulates liver tumor-initiating cells expansion by targeting TP53INP1 and predicts Sorafenib resistance
por: Huang, Yonggang, et al.
Publicado: (2020)

Downregulation of microRNA-3934-5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1
por: Ye, Wei, et al.
Publicado: (2019)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bu3q4q02v9frn2a9mio0osbd5r