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cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents

The definition of metabolic syndrome (MetS) based on dichotomous cut-off points is efficient in the adult population. However, to date, there is no international consensus on how to define MetS in the pediatric population. For that reason, a continuous MetS score (cMetS) has been proposed for the pe...

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Autores principales: Fernández-Aparicio, Ángel, Perona, Javier S., Schmidt-RioValle, Jacqueline, Montero-Alonso, Miguel A., Navarro-Pérez, Carmen Flores, González-Jiménez, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865991/
https://www.ncbi.nlm.nih.gov/pubmed/36675671
http://dx.doi.org/10.3390/jpm13010010
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author Fernández-Aparicio, Ángel
Perona, Javier S.
Schmidt-RioValle, Jacqueline
Montero-Alonso, Miguel A.
Navarro-Pérez, Carmen Flores
González-Jiménez, Emilio
author_facet Fernández-Aparicio, Ángel
Perona, Javier S.
Schmidt-RioValle, Jacqueline
Montero-Alonso, Miguel A.
Navarro-Pérez, Carmen Flores
González-Jiménez, Emilio
author_sort Fernández-Aparicio, Ángel
collection PubMed
description The definition of metabolic syndrome (MetS) based on dichotomous cut-off points is efficient in the adult population. However, to date, there is no international consensus on how to define MetS in the pediatric population. For that reason, a continuous MetS score (cMetS) has been proposed for the pediatric population. However, despite multiple attempts, cMetS has not been fully validated as there is no agreement about the most accurate score to calculate it. The purpose of the present study was to compare the validity of different scores (three siMS scores, z-score, principal components analysis (PCA), the sum of PCA, and confirmatory factor analysis) to calculate cMetS and determine MetS in Spanish adolescents. There were 981 subjects, ranging 11–16 years old, recruited for this cross-sectional study. Seven different approaches to pediatric cMetS scores were calculated. All cMetS scores calculated strongly correlated with each other, especially siMS scores. The area under the curve obtained from receiving operating characteristic curves was particularly elevated for z-scores 0.81 (95% CI: 0.784–0.838), showing a specificity of 64.4%. Our study shows that cMetS based on z-scores is accurate and efficient to be used for research instead of the dichotomized definition of MetS in adolescents; and cMetS based on siMS scores is useful for clinical practice.
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spelling pubmed-98659912023-01-22 cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents Fernández-Aparicio, Ángel Perona, Javier S. Schmidt-RioValle, Jacqueline Montero-Alonso, Miguel A. Navarro-Pérez, Carmen Flores González-Jiménez, Emilio J Pers Med Article The definition of metabolic syndrome (MetS) based on dichotomous cut-off points is efficient in the adult population. However, to date, there is no international consensus on how to define MetS in the pediatric population. For that reason, a continuous MetS score (cMetS) has been proposed for the pediatric population. However, despite multiple attempts, cMetS has not been fully validated as there is no agreement about the most accurate score to calculate it. The purpose of the present study was to compare the validity of different scores (three siMS scores, z-score, principal components analysis (PCA), the sum of PCA, and confirmatory factor analysis) to calculate cMetS and determine MetS in Spanish adolescents. There were 981 subjects, ranging 11–16 years old, recruited for this cross-sectional study. Seven different approaches to pediatric cMetS scores were calculated. All cMetS scores calculated strongly correlated with each other, especially siMS scores. The area under the curve obtained from receiving operating characteristic curves was particularly elevated for z-scores 0.81 (95% CI: 0.784–0.838), showing a specificity of 64.4%. Our study shows that cMetS based on z-scores is accurate and efficient to be used for research instead of the dichotomized definition of MetS in adolescents; and cMetS based on siMS scores is useful for clinical practice. MDPI 2022-12-21 /pmc/articles/PMC9865991/ /pubmed/36675671 http://dx.doi.org/10.3390/jpm13010010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernández-Aparicio, Ángel
Perona, Javier S.
Schmidt-RioValle, Jacqueline
Montero-Alonso, Miguel A.
Navarro-Pérez, Carmen Flores
González-Jiménez, Emilio
cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title_full cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title_fullStr cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title_full_unstemmed cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title_short cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents
title_sort cmets based on z-scores as an accurate and efficient scoring system to determine metabolic syndrome in spanish adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865991/
https://www.ncbi.nlm.nih.gov/pubmed/36675671
http://dx.doi.org/10.3390/jpm13010010
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