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Vancomycin Resistance in Enterococcus and Staphylococcus aureus

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common commensals and major opportunistic human pathogens. In recent decades, these bacteria have acquired broad resistance to several major classes of antibiotics, including commonly employed glycopeptides. Exemplified b...

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Autores principales: Li, Gen, Walker, Mark J., De Oliveira, David M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866002/
https://www.ncbi.nlm.nih.gov/pubmed/36677316
http://dx.doi.org/10.3390/microorganisms11010024
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author Li, Gen
Walker, Mark J.
De Oliveira, David M. P.
author_facet Li, Gen
Walker, Mark J.
De Oliveira, David M. P.
author_sort Li, Gen
collection PubMed
description Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common commensals and major opportunistic human pathogens. In recent decades, these bacteria have acquired broad resistance to several major classes of antibiotics, including commonly employed glycopeptides. Exemplified by resistance to vancomycin, glycopeptide resistance is mediated through intrinsic gene mutations, and/or transferrable van resistance gene cassette-carrying mobile genetic elements. Here, this review will discuss the epidemiology of vancomycin-resistant Enterococcus and S. aureus in healthcare, community, and agricultural settings, explore vancomycin resistance in the context of van and non-van mediated resistance development and provide insights into alternative therapeutic approaches aimed at treating drug-resistant Enterococcus and S. aureus infections.
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spelling pubmed-98660022023-01-22 Vancomycin Resistance in Enterococcus and Staphylococcus aureus Li, Gen Walker, Mark J. De Oliveira, David M. P. Microorganisms Review Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common commensals and major opportunistic human pathogens. In recent decades, these bacteria have acquired broad resistance to several major classes of antibiotics, including commonly employed glycopeptides. Exemplified by resistance to vancomycin, glycopeptide resistance is mediated through intrinsic gene mutations, and/or transferrable van resistance gene cassette-carrying mobile genetic elements. Here, this review will discuss the epidemiology of vancomycin-resistant Enterococcus and S. aureus in healthcare, community, and agricultural settings, explore vancomycin resistance in the context of van and non-van mediated resistance development and provide insights into alternative therapeutic approaches aimed at treating drug-resistant Enterococcus and S. aureus infections. MDPI 2022-12-21 /pmc/articles/PMC9866002/ /pubmed/36677316 http://dx.doi.org/10.3390/microorganisms11010024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Gen
Walker, Mark J.
De Oliveira, David M. P.
Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title_full Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title_fullStr Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title_full_unstemmed Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title_short Vancomycin Resistance in Enterococcus and Staphylococcus aureus
title_sort vancomycin resistance in enterococcus and staphylococcus aureus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866002/
https://www.ncbi.nlm.nih.gov/pubmed/36677316
http://dx.doi.org/10.3390/microorganisms11010024
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