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Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases

The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the present review, we introduce neurodevelopmental and...

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Autores principales: Ishihara, Keiichi, Takata, Kazuyuki, Mizutani, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866034/
https://www.ncbi.nlm.nih.gov/pubmed/36676170
http://dx.doi.org/10.3390/life13010221
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author Ishihara, Keiichi
Takata, Kazuyuki
Mizutani, Ken-ichi
author_facet Ishihara, Keiichi
Takata, Kazuyuki
Mizutani, Ken-ichi
author_sort Ishihara, Keiichi
collection PubMed
description The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the present review, we introduce neurodevelopmental and neuropsychiatric diseases potentially caused by disturbances in the neurovascular system and discuss candidate genes responsible for neurovascular system impairments. In contrast to diseases that can manifest during the developing stage, we have also summarized the disturbances of the neurovascular system in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Furthermore, we discussed the role of abnormal vascularization and dysfunctional vessels in the development of neurovascular-related diseases.
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spelling pubmed-98660342023-01-22 Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases Ishihara, Keiichi Takata, Kazuyuki Mizutani, Ken-ichi Life (Basel) Review The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the present review, we introduce neurodevelopmental and neuropsychiatric diseases potentially caused by disturbances in the neurovascular system and discuss candidate genes responsible for neurovascular system impairments. In contrast to diseases that can manifest during the developing stage, we have also summarized the disturbances of the neurovascular system in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Furthermore, we discussed the role of abnormal vascularization and dysfunctional vessels in the development of neurovascular-related diseases. MDPI 2023-01-12 /pmc/articles/PMC9866034/ /pubmed/36676170 http://dx.doi.org/10.3390/life13010221 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ishihara, Keiichi
Takata, Kazuyuki
Mizutani, Ken-ichi
Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title_full Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title_fullStr Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title_full_unstemmed Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title_short Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
title_sort involvement of an aberrant vascular system in neurodevelopmental, neuropsychiatric, and neuro-degenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866034/
https://www.ncbi.nlm.nih.gov/pubmed/36676170
http://dx.doi.org/10.3390/life13010221
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