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First Report of Neocucurbitaria unguis-hominis Keratitis

Coelomycetous fungi are among the emerging causes of infections and have been involved in many kinds of infections, including keratitis and endophtalmitis. Here, we present the first case of keratitis caused by Neocucurbitaria unguis-hominis, a coelomycetous fungus belonging to the family Cucurbitar...

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Autores principales: Sáenz-Madrazo, Nerea, Baeza, Azucena, Guinea, Jesús, Martín-Rabadán, Pablo, Ruiz-Velasco-Santacruz, Alejandro, Urcelay, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866073/
https://www.ncbi.nlm.nih.gov/pubmed/36675829
http://dx.doi.org/10.3390/jof9010008
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author Sáenz-Madrazo, Nerea
Baeza, Azucena
Guinea, Jesús
Martín-Rabadán, Pablo
Ruiz-Velasco-Santacruz, Alejandro
Urcelay, José Luis
author_facet Sáenz-Madrazo, Nerea
Baeza, Azucena
Guinea, Jesús
Martín-Rabadán, Pablo
Ruiz-Velasco-Santacruz, Alejandro
Urcelay, José Luis
author_sort Sáenz-Madrazo, Nerea
collection PubMed
description Coelomycetous fungi are among the emerging causes of infections and have been involved in many kinds of infections, including keratitis and endophtalmitis. Here, we present the first case of keratitis caused by Neocucurbitaria unguis-hominis, a coelomycetous fungus belonging to the family Cucurbitariaceae. In this case report, we describe the clinical presentation of a 56-year-old woman, a regular contact lens wearer, who was treated for pain in her right eye and fixed spot vision after an injury with plant debris. On examination, a corneal ulcer was observed, the foreign body was removed, and topical eye-drop therapy was started. After an initial improvement, the patient returned three weeks later due to a recurrence of discomfort in her right eye, observing the persistence of the corneal ulcer. Corneal scrapings were taken for culture, growing a filamentous fungus after seven days, which was identified by sequencing the fungal internal transcribed spacer region. It should be noted that microbiological identification of the coelomycetes in the clinical laboratory is not easy because of their difficulty in sporulating, making molecular techniques based on the amplification and sequencing of appropriate phylogenetic markers essential. Identification of these fungi is mandatory in order to optimise treatment due to the difficulty in eradicating them with antifungal treatment, requiring surgery in 50% of cases.
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spelling pubmed-98660732023-01-22 First Report of Neocucurbitaria unguis-hominis Keratitis Sáenz-Madrazo, Nerea Baeza, Azucena Guinea, Jesús Martín-Rabadán, Pablo Ruiz-Velasco-Santacruz, Alejandro Urcelay, José Luis J Fungi (Basel) Case Report Coelomycetous fungi are among the emerging causes of infections and have been involved in many kinds of infections, including keratitis and endophtalmitis. Here, we present the first case of keratitis caused by Neocucurbitaria unguis-hominis, a coelomycetous fungus belonging to the family Cucurbitariaceae. In this case report, we describe the clinical presentation of a 56-year-old woman, a regular contact lens wearer, who was treated for pain in her right eye and fixed spot vision after an injury with plant debris. On examination, a corneal ulcer was observed, the foreign body was removed, and topical eye-drop therapy was started. After an initial improvement, the patient returned three weeks later due to a recurrence of discomfort in her right eye, observing the persistence of the corneal ulcer. Corneal scrapings were taken for culture, growing a filamentous fungus after seven days, which was identified by sequencing the fungal internal transcribed spacer region. It should be noted that microbiological identification of the coelomycetes in the clinical laboratory is not easy because of their difficulty in sporulating, making molecular techniques based on the amplification and sequencing of appropriate phylogenetic markers essential. Identification of these fungi is mandatory in order to optimise treatment due to the difficulty in eradicating them with antifungal treatment, requiring surgery in 50% of cases. MDPI 2022-12-21 /pmc/articles/PMC9866073/ /pubmed/36675829 http://dx.doi.org/10.3390/jof9010008 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Sáenz-Madrazo, Nerea
Baeza, Azucena
Guinea, Jesús
Martín-Rabadán, Pablo
Ruiz-Velasco-Santacruz, Alejandro
Urcelay, José Luis
First Report of Neocucurbitaria unguis-hominis Keratitis
title First Report of Neocucurbitaria unguis-hominis Keratitis
title_full First Report of Neocucurbitaria unguis-hominis Keratitis
title_fullStr First Report of Neocucurbitaria unguis-hominis Keratitis
title_full_unstemmed First Report of Neocucurbitaria unguis-hominis Keratitis
title_short First Report of Neocucurbitaria unguis-hominis Keratitis
title_sort first report of neocucurbitaria unguis-hominis keratitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866073/
https://www.ncbi.nlm.nih.gov/pubmed/36675829
http://dx.doi.org/10.3390/jof9010008
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