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Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish

The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expressi...

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Autores principales: de Abreu, Murilo S., Demin, Konstantin A., Kotova, Maria M., Mirzaei, Foad, Shariff, Sanobar, Kantawala, Burhan, Zakharchenko, Ksenia V., Kolesnikova, Tatiana O., Dilbaryan, Karen, Grigoryan, Artem, Yenkoyan, Konstantin B., Kalueff, Allan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866103/
https://www.ncbi.nlm.nih.gov/pubmed/36675042
http://dx.doi.org/10.3390/ijms24021530
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author de Abreu, Murilo S.
Demin, Konstantin A.
Kotova, Maria M.
Mirzaei, Foad
Shariff, Sanobar
Kantawala, Burhan
Zakharchenko, Ksenia V.
Kolesnikova, Tatiana O.
Dilbaryan, Karen
Grigoryan, Artem
Yenkoyan, Konstantin B.
Kalueff, Allan V.
author_facet de Abreu, Murilo S.
Demin, Konstantin A.
Kotova, Maria M.
Mirzaei, Foad
Shariff, Sanobar
Kantawala, Burhan
Zakharchenko, Ksenia V.
Kolesnikova, Tatiana O.
Dilbaryan, Karen
Grigoryan, Artem
Yenkoyan, Konstantin B.
Kalueff, Allan V.
author_sort de Abreu, Murilo S.
collection PubMed
description The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field.
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spelling pubmed-98661032023-01-22 Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish de Abreu, Murilo S. Demin, Konstantin A. Kotova, Maria M. Mirzaei, Foad Shariff, Sanobar Kantawala, Burhan Zakharchenko, Ksenia V. Kolesnikova, Tatiana O. Dilbaryan, Karen Grigoryan, Artem Yenkoyan, Konstantin B. Kalueff, Allan V. Int J Mol Sci Review The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field. MDPI 2023-01-12 /pmc/articles/PMC9866103/ /pubmed/36675042 http://dx.doi.org/10.3390/ijms24021530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Abreu, Murilo S.
Demin, Konstantin A.
Kotova, Maria M.
Mirzaei, Foad
Shariff, Sanobar
Kantawala, Burhan
Zakharchenko, Ksenia V.
Kolesnikova, Tatiana O.
Dilbaryan, Karen
Grigoryan, Artem
Yenkoyan, Konstantin B.
Kalueff, Allan V.
Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title_full Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title_fullStr Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title_full_unstemmed Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title_short Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
title_sort developing novel experimental models of m-toropathic epilepsy and related neuropathologies: translational insights from zebrafish
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866103/
https://www.ncbi.nlm.nih.gov/pubmed/36675042
http://dx.doi.org/10.3390/ijms24021530
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