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Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish
The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expressi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866103/ https://www.ncbi.nlm.nih.gov/pubmed/36675042 http://dx.doi.org/10.3390/ijms24021530 |
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author | de Abreu, Murilo S. Demin, Konstantin A. Kotova, Maria M. Mirzaei, Foad Shariff, Sanobar Kantawala, Burhan Zakharchenko, Ksenia V. Kolesnikova, Tatiana O. Dilbaryan, Karen Grigoryan, Artem Yenkoyan, Konstantin B. Kalueff, Allan V. |
author_facet | de Abreu, Murilo S. Demin, Konstantin A. Kotova, Maria M. Mirzaei, Foad Shariff, Sanobar Kantawala, Burhan Zakharchenko, Ksenia V. Kolesnikova, Tatiana O. Dilbaryan, Karen Grigoryan, Artem Yenkoyan, Konstantin B. Kalueff, Allan V. |
author_sort | de Abreu, Murilo S. |
collection | PubMed |
description | The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field. |
format | Online Article Text |
id | pubmed-9866103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98661032023-01-22 Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish de Abreu, Murilo S. Demin, Konstantin A. Kotova, Maria M. Mirzaei, Foad Shariff, Sanobar Kantawala, Burhan Zakharchenko, Ksenia V. Kolesnikova, Tatiana O. Dilbaryan, Karen Grigoryan, Artem Yenkoyan, Konstantin B. Kalueff, Allan V. Int J Mol Sci Review The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed ‘mTORopathies’. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field. MDPI 2023-01-12 /pmc/articles/PMC9866103/ /pubmed/36675042 http://dx.doi.org/10.3390/ijms24021530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Abreu, Murilo S. Demin, Konstantin A. Kotova, Maria M. Mirzaei, Foad Shariff, Sanobar Kantawala, Burhan Zakharchenko, Ksenia V. Kolesnikova, Tatiana O. Dilbaryan, Karen Grigoryan, Artem Yenkoyan, Konstantin B. Kalueff, Allan V. Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title | Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title_full | Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title_fullStr | Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title_full_unstemmed | Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title_short | Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish |
title_sort | developing novel experimental models of m-toropathic epilepsy and related neuropathologies: translational insights from zebrafish |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866103/ https://www.ncbi.nlm.nih.gov/pubmed/36675042 http://dx.doi.org/10.3390/ijms24021530 |
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