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Approaching the Dimerization Mechanism of Small Molecule Inhibitors Targeting PD-L1 with Molecular Simulation

Inhibitors blocking the PD-1/PD-L1 immune checkpoint demonstrate impressive anti-tumor immunity, and small molecule inhibitors disclosed by the Bristol-Myers Squibb (BMS) company have become a hot topic. In this work, by modifying the carbonyl group of BMS-202 into a hydroxyl group to achieve two en...

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Detalles Bibliográficos
Autores principales:	Liang, Jianhuai, Wang, Bingfeng, Yang, Yang, Liu, Boping, Jin, Yulong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866166/ https://www.ncbi.nlm.nih.gov/pubmed/36674800 http://dx.doi.org/10.3390/ijms24021280

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