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Potential Role of Copper in Diabetes and Diabetic Kidney Disease

Copper is a fundamental element for the homeostasis of the body. It is the third most abundant essential transition metal in humans. Changes in the concentration of copper in the blood are responsible for numerous diseases affecting various organs, including the heart, brain, kidneys, and liver. Eve...

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Autores principales: Gembillo, Guido, Labbozzetta, Vincenzo, Giuffrida, Alfio Edoardo, Peritore, Luigi, Calabrese, Vincenzo, Spinella, Claudia, Stancanelli, Maria Rita, Spallino, Eugenia, Visconti, Luca, Santoro, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866181/
https://www.ncbi.nlm.nih.gov/pubmed/36676942
http://dx.doi.org/10.3390/metabo13010017
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author Gembillo, Guido
Labbozzetta, Vincenzo
Giuffrida, Alfio Edoardo
Peritore, Luigi
Calabrese, Vincenzo
Spinella, Claudia
Stancanelli, Maria Rita
Spallino, Eugenia
Visconti, Luca
Santoro, Domenico
author_facet Gembillo, Guido
Labbozzetta, Vincenzo
Giuffrida, Alfio Edoardo
Peritore, Luigi
Calabrese, Vincenzo
Spinella, Claudia
Stancanelli, Maria Rita
Spallino, Eugenia
Visconti, Luca
Santoro, Domenico
author_sort Gembillo, Guido
collection PubMed
description Copper is a fundamental element for the homeostasis of the body. It is the third most abundant essential transition metal in humans. Changes in the concentration of copper in the blood are responsible for numerous diseases affecting various organs, including the heart, brain, kidneys, and liver. Even small copper deficiencies can lead to the development and progression of several pathologies. On the other hand, excessive exposure to copper can cause toxicity in many human organs, leading to various systemic alterations. In the kidney, increased copper concentration in the blood can cause deposition of this element in the kidneys, leading to nephrotoxicity. One of the most interesting aspects of copper balance is its influence on diabetes and the progression of its complications, such as Diabetic Kidney Disease (DKD). Several studies have shown a close relationship between copper serum levels and altered glycemic control. An imbalance of copper can lead to the progression of diabetes-related complications and impaired antioxidant homeostasis. A high Zinc/Copper (Zn/Cu) ratio is associated with improved renal function and reduced risk of poor glycemic control in patients with type two diabetes mellitus (T2DM). Furthermore, the progression of DKD appears to be related to the extent of urinary copper excretion, while regulation of adequate serum copper concentration appears to prevent and treat DKD. The aim of this review is to evaluate the possible role of copper in DKD patients.
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spelling pubmed-98661812023-01-22 Potential Role of Copper in Diabetes and Diabetic Kidney Disease Gembillo, Guido Labbozzetta, Vincenzo Giuffrida, Alfio Edoardo Peritore, Luigi Calabrese, Vincenzo Spinella, Claudia Stancanelli, Maria Rita Spallino, Eugenia Visconti, Luca Santoro, Domenico Metabolites Review Copper is a fundamental element for the homeostasis of the body. It is the third most abundant essential transition metal in humans. Changes in the concentration of copper in the blood are responsible for numerous diseases affecting various organs, including the heart, brain, kidneys, and liver. Even small copper deficiencies can lead to the development and progression of several pathologies. On the other hand, excessive exposure to copper can cause toxicity in many human organs, leading to various systemic alterations. In the kidney, increased copper concentration in the blood can cause deposition of this element in the kidneys, leading to nephrotoxicity. One of the most interesting aspects of copper balance is its influence on diabetes and the progression of its complications, such as Diabetic Kidney Disease (DKD). Several studies have shown a close relationship between copper serum levels and altered glycemic control. An imbalance of copper can lead to the progression of diabetes-related complications and impaired antioxidant homeostasis. A high Zinc/Copper (Zn/Cu) ratio is associated with improved renal function and reduced risk of poor glycemic control in patients with type two diabetes mellitus (T2DM). Furthermore, the progression of DKD appears to be related to the extent of urinary copper excretion, while regulation of adequate serum copper concentration appears to prevent and treat DKD. The aim of this review is to evaluate the possible role of copper in DKD patients. MDPI 2022-12-22 /pmc/articles/PMC9866181/ /pubmed/36676942 http://dx.doi.org/10.3390/metabo13010017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gembillo, Guido
Labbozzetta, Vincenzo
Giuffrida, Alfio Edoardo
Peritore, Luigi
Calabrese, Vincenzo
Spinella, Claudia
Stancanelli, Maria Rita
Spallino, Eugenia
Visconti, Luca
Santoro, Domenico
Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title_full Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title_fullStr Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title_full_unstemmed Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title_short Potential Role of Copper in Diabetes and Diabetic Kidney Disease
title_sort potential role of copper in diabetes and diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866181/
https://www.ncbi.nlm.nih.gov/pubmed/36676942
http://dx.doi.org/10.3390/metabo13010017
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