Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis

Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of different acute (myocardial infarction) or chronic (diabetes, hypertension, …) diseases but also due to genetic alterations or aging. Currently, there is no curative treatment that is able to prevent or attenu...

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Autores principales: Bertaud, Alexandrine, Joshkon, Ahmad, Heim, Xavier, Bachelier, Richard, Bardin, Nathalie, Leroyer, Aurélie S., Blot-Chabaud, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866199/
https://www.ncbi.nlm.nih.gov/pubmed/36675283
http://dx.doi.org/10.3390/ijms24021756
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author Bertaud, Alexandrine
Joshkon, Ahmad
Heim, Xavier
Bachelier, Richard
Bardin, Nathalie
Leroyer, Aurélie S.
Blot-Chabaud, Marcel
author_facet Bertaud, Alexandrine
Joshkon, Ahmad
Heim, Xavier
Bachelier, Richard
Bardin, Nathalie
Leroyer, Aurélie S.
Blot-Chabaud, Marcel
author_sort Bertaud, Alexandrine
collection PubMed
description Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of different acute (myocardial infarction) or chronic (diabetes, hypertension, …) diseases but also due to genetic alterations or aging. Currently, there is no curative treatment that is able to prevent or attenuate this phenomenon that leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes the different targets identified and the new strategies proposed to fight cardiac fibrosis. Future directions, including the use of exosomes or nanoparticles, will also be discussed.
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spelling pubmed-98661992023-01-22 Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis Bertaud, Alexandrine Joshkon, Ahmad Heim, Xavier Bachelier, Richard Bardin, Nathalie Leroyer, Aurélie S. Blot-Chabaud, Marcel Int J Mol Sci Review Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of different acute (myocardial infarction) or chronic (diabetes, hypertension, …) diseases but also due to genetic alterations or aging. Currently, there is no curative treatment that is able to prevent or attenuate this phenomenon that leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes the different targets identified and the new strategies proposed to fight cardiac fibrosis. Future directions, including the use of exosomes or nanoparticles, will also be discussed. MDPI 2023-01-16 /pmc/articles/PMC9866199/ /pubmed/36675283 http://dx.doi.org/10.3390/ijms24021756 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bertaud, Alexandrine
Joshkon, Ahmad
Heim, Xavier
Bachelier, Richard
Bardin, Nathalie
Leroyer, Aurélie S.
Blot-Chabaud, Marcel
Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title_full Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title_fullStr Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title_full_unstemmed Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title_short Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
title_sort signaling pathways and potential therapeutic strategies in cardiac fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866199/
https://www.ncbi.nlm.nih.gov/pubmed/36675283
http://dx.doi.org/10.3390/ijms24021756
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