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Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1

A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da. The full chemical synthesis and proper folding of Cm39 was obtained. Based on amino acid sequence alignmen...

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Detalles Bibliográficos
Autores principales:	Naseem, Muhammad Umair, Gurrola-Briones, Georgina, Romero-Imbachi, Margarita R., Borrego, Jesus, Carcamo-Noriega, Edson, Beltrán-Vidal, José, Zamudio, Fernando Z., Shakeel, Kashmala, Possani, Lourival Domingos, Panyi, Gyorgy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866218/ https://www.ncbi.nlm.nih.gov/pubmed/36668861 http://dx.doi.org/10.3390/toxins15010041

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