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Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts

Early diagnosis is essential for completely eradicating skin cancer and maximizing patients’ clinical benefits. Emerging optical imaging modalities such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT), magnetic resonance imaging (MRI), near-infrared (NIR) bioimaging, pos...

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Autores principales: Dobre, Elena-Georgiana, Surcel, Mihaela, Constantin, Carolina, Ilie, Mihaela Adriana, Caruntu, Ana, Caruntu, Constantin, Neagu, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866322/
https://www.ncbi.nlm.nih.gov/pubmed/36674595
http://dx.doi.org/10.3390/ijms24021079
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author Dobre, Elena-Georgiana
Surcel, Mihaela
Constantin, Carolina
Ilie, Mihaela Adriana
Caruntu, Ana
Caruntu, Constantin
Neagu, Monica
author_facet Dobre, Elena-Georgiana
Surcel, Mihaela
Constantin, Carolina
Ilie, Mihaela Adriana
Caruntu, Ana
Caruntu, Constantin
Neagu, Monica
author_sort Dobre, Elena-Georgiana
collection PubMed
description Early diagnosis is essential for completely eradicating skin cancer and maximizing patients’ clinical benefits. Emerging optical imaging modalities such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT), magnetic resonance imaging (MRI), near-infrared (NIR) bioimaging, positron emission tomography (PET), and their combinations provide non-invasive imaging data that may help in the early detection of cutaneous tumors and surgical planning. Hence, they seem appropriate for observing dynamic processes such as blood flow, immune cell activation, and tumor energy metabolism, which may be relevant for disease evolution. This review discusses the latest technological and methodological advances in imaging techniques that may be applied for skin cancer detection and monitoring. In the first instance, we will describe the principle and prospective clinical applications of the most commonly used imaging techniques, highlighting the challenges and opportunities of their implementation in the clinical setting. We will also highlight how imaging techniques may complement the molecular and histological approaches in sharpening the non-invasive skin characterization, laying the ground for more personalized approaches in skin cancer patients.
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spelling pubmed-98663222023-01-22 Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts Dobre, Elena-Georgiana Surcel, Mihaela Constantin, Carolina Ilie, Mihaela Adriana Caruntu, Ana Caruntu, Constantin Neagu, Monica Int J Mol Sci Review Early diagnosis is essential for completely eradicating skin cancer and maximizing patients’ clinical benefits. Emerging optical imaging modalities such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT), magnetic resonance imaging (MRI), near-infrared (NIR) bioimaging, positron emission tomography (PET), and their combinations provide non-invasive imaging data that may help in the early detection of cutaneous tumors and surgical planning. Hence, they seem appropriate for observing dynamic processes such as blood flow, immune cell activation, and tumor energy metabolism, which may be relevant for disease evolution. This review discusses the latest technological and methodological advances in imaging techniques that may be applied for skin cancer detection and monitoring. In the first instance, we will describe the principle and prospective clinical applications of the most commonly used imaging techniques, highlighting the challenges and opportunities of their implementation in the clinical setting. We will also highlight how imaging techniques may complement the molecular and histological approaches in sharpening the non-invasive skin characterization, laying the ground for more personalized approaches in skin cancer patients. MDPI 2023-01-05 /pmc/articles/PMC9866322/ /pubmed/36674595 http://dx.doi.org/10.3390/ijms24021079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dobre, Elena-Georgiana
Surcel, Mihaela
Constantin, Carolina
Ilie, Mihaela Adriana
Caruntu, Ana
Caruntu, Constantin
Neagu, Monica
Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title_full Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title_fullStr Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title_full_unstemmed Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title_short Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts
title_sort skin cancer pathobiology at a glance: a focus on imaging techniques and their potential for improved diagnosis and surveillance in clinical cohorts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866322/
https://www.ncbi.nlm.nih.gov/pubmed/36674595
http://dx.doi.org/10.3390/ijms24021079
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