Cargando…

Cysteamine/Cystamine Exert Anti-Mycobacterium abscessus Activity Alone or in Combination with Amikacin

Host-directed therapies are emerging as a promising tool in the curing of difficult-to-treat infections, such as those caused by drug-resistant bacteria. In this study, we aim to test the potential activity of the FDA- and EMA-approved drugs cysteamine and cystamine against Mycobacterium abscessus....

Descripción completa

Detalles Bibliográficos
Autores principales:	Palucci, Ivana, Salustri, Alessandro, De Maio, Flavio, Pereyra Boza, Maria del Carmen, Paglione, Francesco, Sali, Michela, Occhigrossi, Luca, D’Eletto, Manuela, Rossin, Federica, Goletti, Delia, Sanguinetti, Maurizio, Piacentini, Mauro, Delogu, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866335/ https://www.ncbi.nlm.nih.gov/pubmed/36674717 http://dx.doi.org/10.3390/ijms24021203

Ejemplares similares

Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo
por: Jeitner, Thomas M., et al.
Publicado: (2018)

Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy
por: Alonzi, Tonino, et al.
Publicado: (2021)

Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases
por: Paul, Bindu D., et al.
Publicado: (2019)

Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
por: Occhigrossi, Luca, et al.
Publicado: (2022)

Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
por: Rossin, Federica, et al.
Publicado: (2023)

The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2
por: Occhigrossi, Luca, et al.
Publicado: (2021)

Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants
por: Alonzi, Tonino, et al.
Publicado: (2022)

Proceedings: Influence of cysteamine or cystamine on radiation late effects in C57BL/6 mice.
por: Mewissen, D. J., et al.
Publicado: (1975)

Simultaneous Determination of Cysteamine and Cystamine in Cosmetics by Ion-Pairing Reversed-Phase High-Performance Liquid Chromatography
por: Kim, Yejin, et al.
Publicado: (2019)

Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis
por: Palucci, Ivana, et al.
Publicado: (2020)

Commercially available CD4 + and CD8 + IFN-γ release assays combined with an HBHA-induced IGRA improve the characterization of the tuberculosis spectrum and monitoring of treatment in children
por: Buonsenso, Danilo, et al.
Publicado: (2023)

Evaluation of Everolimus Activity against Mycobacterium tuberculosis Using In Vitro Models of Infection
por: Bianco, Delia Mercedes, et al.
Publicado: (2023)

Amikacin exposure and susceptibility of macrolide-resistant Mycobacterium abscessus
por: Daniel-Wayman, Shelby, et al.
Publicado: (2019)

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation
por: Ferrari, Eleonora, et al.
Publicado: (2017)

Inducible Resistance to Amikacin in Mycobacterium abscessus Isolated in Beijing, China
por: Zhang, Zhijian, et al.
Publicado: (2022)

Comparison of two-drug combinations, amikacin/tigecycline/imipenem and amikacin/tigecycline/clarithromycin against Mycobacteroides abscessus subsp. abscessus using the in vitro time-kill assay
por: Portell-Buj, Elena, et al.
Publicado: (2021)

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
por: Occhigrossi, Luca, et al.
Publicado: (2023)

PE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction between M. tuberculosis and host cells
por: De Maio, Flavio, et al.
Publicado: (2021)

Cystamine Preparations Exhibit Anticoagulant Activity
por: Aleman, Maria M., et al.
Publicado: (2015)

Evaluation of the Toxic Activity of the Graphene Oxide in the Ex Vivo Model of Human PBMC Infection with Mycobacterium tuberculosis
por: Salustri, Alessandro, et al.
Publicado: (2023)

Cysteamine, an Endogenous Aminothiol, and Cystamine, the Disulfide Product of Oxidation, Increase Pseudomonas aeruginosa Sensitivity to Reactive Oxygen and Nitrogen Species and Potentiate Therapeutic Antibiotics against Bacterial Infection
por: Fraser-Pitt, Douglas J., et al.
Publicado: (2018)

Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates
por: Rossin, Federica, et al.
Publicado: (2021)

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis
por: Camassa, Serena, et al.
Publicado: (2017)

Graphene Oxide-Linezolid Combination as Potential New Anti-Tuberculosis Treatment
por: De Maio, Flavio, et al.
Publicado: (2020)

Treatment Outcome in Patients with Mycobacterium abscessus Complex Lung Disease: The Impact of Tigecycline and Amikacin
por: Yang, Jeng-How, et al.
Publicado: (2022)

Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2
por: Piacentini, Mauro, et al.
Publicado: (2018)

Transglutaminase 2 and Ferroptosis: a new liaison?
por: Gagliardi, Mara, et al.
Publicado: (2023)

Accuracy of QuantiFERON-TB Gold Test for Tuberculosis Diagnosis in Children
por: Sali, Michela, et al.
Publicado: (2015)

Synthesis and Characterization of Healable Waterborne Polyurethanes with Cystamine Chain Extenders
por: Lee, Dae-Il, et al.
Publicado: (2019)

Rapid Detection of Clarithromycin and Amikacin Resistance in Mycobacterium abscessus Complex by High-Resolution Melting Curve Analysis
por: Li, Haoran, et al.
Publicado: (2022)

Amikacin Liposomal Inhalation Suspension in the Treatment of Mycobacterium abscessus Lung Infection: A French Observational Experience
por: Chiron, Raphael, et al.
Publicado: (2022)

Graphene nanoplatelet and graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2
por: De Maio, Flavio, et al.
Publicado: (2021)

Effects of Cystamine on antioxidant activities and regulatory T cells in lupus-prone mice
por: Hsu, Tsai-Ching, et al.
Publicado: (2013)

Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid
por: Nanda, Sitansu Sekhar, et al.
Publicado: (2015)

Safety and Outcomes of Amikacin Liposome Inhalation Suspension for Mycobacterium abscessus Pulmonary Disease: A NTM-NET study
por: Henriette Zweijpfenning, Sanne Maria, et al.
Publicado: (2022)

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
por: Romagnoli, Alessandra, et al.
Publicado: (2023)

Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1β-induced autophagy
por: Romagnoli, Alessandra, et al.
Publicado: (2018)

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
por: Altuntas, Sara, et al.
Publicado: (2015)

Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states
por: Piacentini, Mauro, et al.
Publicado: (2014)

Reticulon Homology Domain-Containing Proteins and ER-Phagy
por: D’Eletto, Manuela, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b0dmn6fu714e91t6q90f3o0k9b