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Therapeutic Strategies to Activate p53
The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866379/ https://www.ncbi.nlm.nih.gov/pubmed/36678521 http://dx.doi.org/10.3390/ph16010024 |
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author | Aguilar, Angelo Wang, Shaomeng |
author_facet | Aguilar, Angelo Wang, Shaomeng |
author_sort | Aguilar, Angelo |
collection | PubMed |
description | The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53. |
format | Online Article Text |
id | pubmed-9866379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98663792023-01-22 Therapeutic Strategies to Activate p53 Aguilar, Angelo Wang, Shaomeng Pharmaceuticals (Basel) Review The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53. MDPI 2022-12-24 /pmc/articles/PMC9866379/ /pubmed/36678521 http://dx.doi.org/10.3390/ph16010024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aguilar, Angelo Wang, Shaomeng Therapeutic Strategies to Activate p53 |
title | Therapeutic Strategies to Activate p53 |
title_full | Therapeutic Strategies to Activate p53 |
title_fullStr | Therapeutic Strategies to Activate p53 |
title_full_unstemmed | Therapeutic Strategies to Activate p53 |
title_short | Therapeutic Strategies to Activate p53 |
title_sort | therapeutic strategies to activate p53 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866379/ https://www.ncbi.nlm.nih.gov/pubmed/36678521 http://dx.doi.org/10.3390/ph16010024 |
work_keys_str_mv | AT aguilarangelo therapeuticstrategiestoactivatep53 AT wangshaomeng therapeuticstrategiestoactivatep53 |