Therapeutic Strategies to Activate p53

The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulat...

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Detalles Bibliográficos
Autores principales: Aguilar, Angelo, Wang, Shaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866379/
https://www.ncbi.nlm.nih.gov/pubmed/36678521
http://dx.doi.org/10.3390/ph16010024
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author Aguilar, Angelo
Wang, Shaomeng
author_facet Aguilar, Angelo
Wang, Shaomeng
author_sort Aguilar, Angelo
collection PubMed
description The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53.
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spelling pubmed-98663792023-01-22 Therapeutic Strategies to Activate p53 Aguilar, Angelo Wang, Shaomeng Pharmaceuticals (Basel) Review The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53. MDPI 2022-12-24 /pmc/articles/PMC9866379/ /pubmed/36678521 http://dx.doi.org/10.3390/ph16010024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aguilar, Angelo
Wang, Shaomeng
Therapeutic Strategies to Activate p53
title Therapeutic Strategies to Activate p53
title_full Therapeutic Strategies to Activate p53
title_fullStr Therapeutic Strategies to Activate p53
title_full_unstemmed Therapeutic Strategies to Activate p53
title_short Therapeutic Strategies to Activate p53
title_sort therapeutic strategies to activate p53
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866379/
https://www.ncbi.nlm.nih.gov/pubmed/36678521
http://dx.doi.org/10.3390/ph16010024
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