Cargando…
Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis
The Δ133p53β isoform is increased in many primary tumors and has many tumor-promoting properties that contribute to increased proliferation, migration and inflammation. Here we investigated whether Δ133p53β contributed to some of the most aggressive tumors that had metastasized to the brain. Δ133p53...
Autores principales: | Jesus, Alexandra N. Boix De, Taha, Ahmad, Wang, David, Mehta, Paulomi M., Mehta, Sunali, Reily-Bell, Ashley, Lekamlage, Sasini Polwatta, Saraiva, Adriana Machado, Tahmeedzaman, Tahmeed, Ziad, Fouzia, Thotathil, Ziad, Gan, Peter Y. C., Royds, Janice, Braithwaite, Antony, Hung, Noelyn, Slatter, Tania L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866425/ https://www.ncbi.nlm.nih.gov/pubmed/36674782 http://dx.doi.org/10.3390/ijms24021267 |
Ejemplares similares
-
Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development
por: Kazantseva, Marina, et al.
Publicado: (2018) -
The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
por: Kazantseva, Marina, et al.
Publicado: (2019) -
Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk
por: Eiholzer, Ramona A., et al.
Publicado: (2020) -
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
por: Arsic, Nikola, et al.
Publicado: (2021) -
Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis
por: Wiles, Anna K., et al.
Publicado: (2023)