Cargando…

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol’s Anti-Tumor Angiogenesis Effect

Celastrol, an active triterpenoid extracted from one of the most famous traditional Chinese medicines (TCMs), Tripterygium wilfordii Hook.f., is a novel anti-cancer drug with significant anti-angiogenesis activity. However, the exact molecular mechanisms underlying its anti-tumor angiogenesis effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Gaofu, Zhou, Lei, Deng, Huifang, Huang, Congshu, Wang, Ningning, Yue, Lanxin, Zhang, Pengfei, Zhou, Yongqiang, Zhou, Wei, Gao, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866574/ https://www.ncbi.nlm.nih.gov/pubmed/36678677 http://dx.doi.org/10.3390/pharmaceutics15010048

Ejemplares similares

Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation
por: Wang, Ningning, et al.
Publicado: (2023)

Autophagy in the pharmacological activities of celastrol (Review)
por: Zhang, Caixia, et al.
Publicado: (2023)

Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia
por: Shen, Xin, et al.
Publicado: (2022)

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane
por: Ge, Yifan, et al.
Publicado: (2020)

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
por: Li, Meng, et al.
Publicado: (2020)

Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
por: Li, Zhanrong, et al.
Publicado: (2020)

OPA1’s shortcut to mitochondrial fission
por: Short, Ben
Publicado: (2014)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
por: Kieper, Nicole, et al.
Publicado: (2010)

MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition
por: Guan, Lichun, et al.
Publicado: (2019)

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
por: Ehses, Sarah, et al.
Publicado: (2009)

Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion
por: Wang, Ruohan, et al.
Publicado: (2021)

Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis
por: Chehaitly, Ahmad, et al.
Publicado: (2022)

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion
por: Cartes-Saavedra, Benjamín, et al.
Publicado: (2023)

Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway
por: Qiu, Li-Zhen, et al.
Publicado: (2021)

Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway
por: YU, XIAOLONG, et al.
Publicado: (2015)

Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function
por: Yu, Xiaowen, et al.
Publicado: (2018)

The Effect of OPA1 on Mitochondrial Ca(2+) Signaling
por: Fülöp, László, et al.
Publicado: (2011)

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
por: Lee, Hakjoo, et al.
Publicado: (2018)

Celastrol Prevents Atherosclerosis via Inhibiting LOX-1 and Oxidative Stress
por: Gu, Lei, et al.
Publicado: (2013)

Melatonin Attenuates Calcium Deposition from Vascular Smooth Muscle Cells by Activating Mitochondrial Fusion and Mitophagy via an AMPK/OPA1 Signaling Pathway
por: Chen, Wei Ren, et al.
Publicado: (2020)

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability
por: Zhou, Bo, et al.
Publicado: (2021)

Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate
por: Wang, X, et al.
Publicado: (2014)

Celastrol inhibits store operated calcium entry and suppresses psoriasis
por: Yuan, Xiaoman, et al.
Publicado: (2023)

Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis
por: Xinqiang, Song, et al.
Publicado: (2020)

OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases
por: Wu, Wei, et al.
Publicado: (2019)

Celastrol inhibits the proliferation and angiogenesis of high glucose-induced human retinal endothelial cells
por: Fang, Jian, et al.
Publicado: (2021)

Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
por: Li, Peng, et al.
Publicado: (2017)

Regulating mitochondrial homeostasis and inhibiting inflammatory responses through Celastrol
por: Tao, Zhenyu, et al.
Publicado: (2022)

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
por: Song, Zhiyin, et al.
Publicado: (2007)

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
por: Anand, Ruchika, et al.
Publicado: (2014)

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion
por: Ge, Yifan, et al.
Publicado: (2021)

Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development
por: Rahn, Jennifer J., et al.
Publicado: (2013)

OPA1 and MICOS Regulate mitochondrial crista dynamics and formation
por: Hu, Chao, et al.
Publicado: (2020)

OPA1, a new mitochondrial target in cancer therapy
por: Herkenne, Stephanie, et al.
Publicado: (2020)

Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
por: Nishikawa, Keizo, et al.
Publicado: (2022)

In situ architecture of Opa1-dependent mitochondrial cristae remodeling
por: Fry, Michelle Y., et al.
Publicado: (2023)

Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib
por: Zhang, Rui, et al.
Publicado: (2019)

The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery
por: Xiao, Simeng, et al.
Publicado: (2023)

Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes
por: Liu, Mengqian, et al.
Publicado: (2023)

Anti-biofilm and Anti-Virulence Efficacy of Celastrol Against Stenotrophomonas maltophilia
por: Kim, Hye-Rim, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9pn98anni5k1pagm258go68676