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The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odor...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866594/ https://www.ncbi.nlm.nih.gov/pubmed/36678327 http://dx.doi.org/10.3390/nu15020455 |
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author | Hammad, Fayez T. Al-Salam, Suhail Ahmad, Rahaf Yasin, Javed Hammad, Awwab F. Rasheed, Jasmine Abdul Lubbad, Loay |
author_facet | Hammad, Fayez T. Al-Salam, Suhail Ahmad, Rahaf Yasin, Javed Hammad, Awwab F. Rasheed, Jasmine Abdul Lubbad, Loay |
author_sort | Hammad, Fayez T. |
collection | PubMed |
description | Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odors and has been proven to be effective for the treatment of some conditions. We investigated the effect of nerolidol in a rat model of renal IRI. Nerolidol was dissolved in a vehicle and administered orally as single daily dose of 200 mg/kg for 5 days prior to IRI and continued for 3 days post IRI. G-Sham (n = 10) underwent sham surgery, whereas G-IRI (n = 10) and G-IRI/NR (n = 10) underwent bilateral warm renal ischemia for 30 min and received the vehicle/nerolidol, respectively. Renal functions and histological changes were assessed before starting the medication, just prior to IRI and 3 days after IRI. Nerolidol significantly attenuated the alterations in serum creatinine and urea, creatinine clearance, urinary albumin and the urinary albumin–creatinine ratio. Nerolidol also significantly attenuated the alterations in markers of kidney injury; proinflammatory, profibrotic and apoptotic cytokines; oxidative stress markers; and histological changes. We conclude that nerolidol has a renoprotective effect on IRI-induced renal dysfunction. These findings might have clinical implications. |
format | Online Article Text |
id | pubmed-9866594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98665942023-01-22 The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat Hammad, Fayez T. Al-Salam, Suhail Ahmad, Rahaf Yasin, Javed Hammad, Awwab F. Rasheed, Jasmine Abdul Lubbad, Loay Nutrients Article Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odors and has been proven to be effective for the treatment of some conditions. We investigated the effect of nerolidol in a rat model of renal IRI. Nerolidol was dissolved in a vehicle and administered orally as single daily dose of 200 mg/kg for 5 days prior to IRI and continued for 3 days post IRI. G-Sham (n = 10) underwent sham surgery, whereas G-IRI (n = 10) and G-IRI/NR (n = 10) underwent bilateral warm renal ischemia for 30 min and received the vehicle/nerolidol, respectively. Renal functions and histological changes were assessed before starting the medication, just prior to IRI and 3 days after IRI. Nerolidol significantly attenuated the alterations in serum creatinine and urea, creatinine clearance, urinary albumin and the urinary albumin–creatinine ratio. Nerolidol also significantly attenuated the alterations in markers of kidney injury; proinflammatory, profibrotic and apoptotic cytokines; oxidative stress markers; and histological changes. We conclude that nerolidol has a renoprotective effect on IRI-induced renal dysfunction. These findings might have clinical implications. MDPI 2023-01-15 /pmc/articles/PMC9866594/ /pubmed/36678327 http://dx.doi.org/10.3390/nu15020455 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hammad, Fayez T. Al-Salam, Suhail Ahmad, Rahaf Yasin, Javed Hammad, Awwab F. Rasheed, Jasmine Abdul Lubbad, Loay The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title | The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title_full | The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title_fullStr | The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title_full_unstemmed | The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title_short | The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat |
title_sort | effect of nerolidol renal dysfunction following ischemia–reperfusion injury in the rat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866594/ https://www.ncbi.nlm.nih.gov/pubmed/36678327 http://dx.doi.org/10.3390/nu15020455 |
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