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The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat

Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odor...

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Autores principales: Hammad, Fayez T., Al-Salam, Suhail, Ahmad, Rahaf, Yasin, Javed, Hammad, Awwab F., Rasheed, Jasmine Abdul, Lubbad, Loay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866594/
https://www.ncbi.nlm.nih.gov/pubmed/36678327
http://dx.doi.org/10.3390/nu15020455
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author Hammad, Fayez T.
Al-Salam, Suhail
Ahmad, Rahaf
Yasin, Javed
Hammad, Awwab F.
Rasheed, Jasmine Abdul
Lubbad, Loay
author_facet Hammad, Fayez T.
Al-Salam, Suhail
Ahmad, Rahaf
Yasin, Javed
Hammad, Awwab F.
Rasheed, Jasmine Abdul
Lubbad, Loay
author_sort Hammad, Fayez T.
collection PubMed
description Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odors and has been proven to be effective for the treatment of some conditions. We investigated the effect of nerolidol in a rat model of renal IRI. Nerolidol was dissolved in a vehicle and administered orally as single daily dose of 200 mg/kg for 5 days prior to IRI and continued for 3 days post IRI. G-Sham (n = 10) underwent sham surgery, whereas G-IRI (n = 10) and G-IRI/NR (n = 10) underwent bilateral warm renal ischemia for 30 min and received the vehicle/nerolidol, respectively. Renal functions and histological changes were assessed before starting the medication, just prior to IRI and 3 days after IRI. Nerolidol significantly attenuated the alterations in serum creatinine and urea, creatinine clearance, urinary albumin and the urinary albumin–creatinine ratio. Nerolidol also significantly attenuated the alterations in markers of kidney injury; proinflammatory, profibrotic and apoptotic cytokines; oxidative stress markers; and histological changes. We conclude that nerolidol has a renoprotective effect on IRI-induced renal dysfunction. These findings might have clinical implications.
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spelling pubmed-98665942023-01-22 The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat Hammad, Fayez T. Al-Salam, Suhail Ahmad, Rahaf Yasin, Javed Hammad, Awwab F. Rasheed, Jasmine Abdul Lubbad, Loay Nutrients Article Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are ongoing. Recently, there has been increasing interest in using natural phytochemical compounds as alternative remedies in several diseases. Nerolidol is a natural product extracted from plants with floral odors and has been proven to be effective for the treatment of some conditions. We investigated the effect of nerolidol in a rat model of renal IRI. Nerolidol was dissolved in a vehicle and administered orally as single daily dose of 200 mg/kg for 5 days prior to IRI and continued for 3 days post IRI. G-Sham (n = 10) underwent sham surgery, whereas G-IRI (n = 10) and G-IRI/NR (n = 10) underwent bilateral warm renal ischemia for 30 min and received the vehicle/nerolidol, respectively. Renal functions and histological changes were assessed before starting the medication, just prior to IRI and 3 days after IRI. Nerolidol significantly attenuated the alterations in serum creatinine and urea, creatinine clearance, urinary albumin and the urinary albumin–creatinine ratio. Nerolidol also significantly attenuated the alterations in markers of kidney injury; proinflammatory, profibrotic and apoptotic cytokines; oxidative stress markers; and histological changes. We conclude that nerolidol has a renoprotective effect on IRI-induced renal dysfunction. These findings might have clinical implications. MDPI 2023-01-15 /pmc/articles/PMC9866594/ /pubmed/36678327 http://dx.doi.org/10.3390/nu15020455 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hammad, Fayez T.
Al-Salam, Suhail
Ahmad, Rahaf
Yasin, Javed
Hammad, Awwab F.
Rasheed, Jasmine Abdul
Lubbad, Loay
The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title_full The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title_fullStr The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title_full_unstemmed The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title_short The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
title_sort effect of nerolidol renal dysfunction following ischemia–reperfusion injury in the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866594/
https://www.ncbi.nlm.nih.gov/pubmed/36678327
http://dx.doi.org/10.3390/nu15020455
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