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GLP-1R Signaling and Functional Molecules in Incretin Therapy
Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting GLP-1R have entered clinical treat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866634/ https://www.ncbi.nlm.nih.gov/pubmed/36677809 http://dx.doi.org/10.3390/molecules28020751 |
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author | Wan, Wenwei Qin, Qikai Xie, Linshan Zhang, Hanqing Wu, Fan Stevens, Raymond C. Liu, Yan |
author_facet | Wan, Wenwei Qin, Qikai Xie, Linshan Zhang, Hanqing Wu, Fan Stevens, Raymond C. Liu, Yan |
author_sort | Wan, Wenwei |
collection | PubMed |
description | Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting GLP-1R have entered clinical treatment. However, novel functional molecules with reduced side effects and enhanced therapeutic efficacy are still in high demand. In this review, we summarize the basis of GLP-1R cellular signaling, and how it is involved in the treatment of T2DM. We review the functional molecules of incretin therapy in various stages of clinical trials. We also outline the current strategies and emerging techniques that are furthering the development of novel therapeutic drugs for T2DM and other metabolic diseases. |
format | Online Article Text |
id | pubmed-9866634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98666342023-01-22 GLP-1R Signaling and Functional Molecules in Incretin Therapy Wan, Wenwei Qin, Qikai Xie, Linshan Zhang, Hanqing Wu, Fan Stevens, Raymond C. Liu, Yan Molecules Review Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and blood glucose regulation has been extensively studied. Numerous drugs targeting GLP-1R have entered clinical treatment. However, novel functional molecules with reduced side effects and enhanced therapeutic efficacy are still in high demand. In this review, we summarize the basis of GLP-1R cellular signaling, and how it is involved in the treatment of T2DM. We review the functional molecules of incretin therapy in various stages of clinical trials. We also outline the current strategies and emerging techniques that are furthering the development of novel therapeutic drugs for T2DM and other metabolic diseases. MDPI 2023-01-11 /pmc/articles/PMC9866634/ /pubmed/36677809 http://dx.doi.org/10.3390/molecules28020751 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wan, Wenwei Qin, Qikai Xie, Linshan Zhang, Hanqing Wu, Fan Stevens, Raymond C. Liu, Yan GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title | GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title_full | GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title_fullStr | GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title_full_unstemmed | GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title_short | GLP-1R Signaling and Functional Molecules in Incretin Therapy |
title_sort | glp-1r signaling and functional molecules in incretin therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866634/ https://www.ncbi.nlm.nih.gov/pubmed/36677809 http://dx.doi.org/10.3390/molecules28020751 |
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