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Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis

Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases such as obesity, type-2 diabetes mellitus (T2DM), and cardiovascular diseases. Emerging evidence suggests that vitamin D deficiency links to cardiometabolic diseases through microbiota. A combination of poor vitamin D st...

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Autores principales: Sukik, Ayah, Alalwani, Joud, Ganji, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866669/
https://www.ncbi.nlm.nih.gov/pubmed/36674452
http://dx.doi.org/10.3390/ijms24020940
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author Sukik, Ayah
Alalwani, Joud
Ganji, Vijay
author_facet Sukik, Ayah
Alalwani, Joud
Ganji, Vijay
author_sort Sukik, Ayah
collection PubMed
description Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases such as obesity, type-2 diabetes mellitus (T2DM), and cardiovascular diseases. Emerging evidence suggests that vitamin D deficiency links to cardiometabolic diseases through microbiota. A combination of poor vitamin D status and dysbiosis may contribute to the progression of cardiometabolic diseases. Therefore, in this review, we present the relationship among vitamin D, microbiota, and cardiometabolic diseases with a focus on MetSyn. We searched major databases for reports on vitamin D, microbiota, and MetSyn until June 2022. We reviewed 13 reports on the relation between vitamin D and MetSyn (6 randomized controlled and 7 cross-sectional studies) and 6 reports on the effect of vitamin D on the gut microbiome. Adequate vitamin D status has a beneficial effect on gut microbiota, therefore preventing the progression of MetSyn. Further, well-controlled studies are needed for a better understanding of the mechanisms of action involving vitamin D and microbiota in the pathogenesis of cardiometabolic diseases.
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spelling pubmed-98666692023-01-22 Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis Sukik, Ayah Alalwani, Joud Ganji, Vijay Int J Mol Sci Review Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases such as obesity, type-2 diabetes mellitus (T2DM), and cardiovascular diseases. Emerging evidence suggests that vitamin D deficiency links to cardiometabolic diseases through microbiota. A combination of poor vitamin D status and dysbiosis may contribute to the progression of cardiometabolic diseases. Therefore, in this review, we present the relationship among vitamin D, microbiota, and cardiometabolic diseases with a focus on MetSyn. We searched major databases for reports on vitamin D, microbiota, and MetSyn until June 2022. We reviewed 13 reports on the relation between vitamin D and MetSyn (6 randomized controlled and 7 cross-sectional studies) and 6 reports on the effect of vitamin D on the gut microbiome. Adequate vitamin D status has a beneficial effect on gut microbiota, therefore preventing the progression of MetSyn. Further, well-controlled studies are needed for a better understanding of the mechanisms of action involving vitamin D and microbiota in the pathogenesis of cardiometabolic diseases. MDPI 2023-01-04 /pmc/articles/PMC9866669/ /pubmed/36674452 http://dx.doi.org/10.3390/ijms24020940 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sukik, Ayah
Alalwani, Joud
Ganji, Vijay
Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title_full Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title_fullStr Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title_full_unstemmed Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title_short Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis
title_sort vitamin d, gut microbiota, and cardiometabolic diseases—a possible three-way axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866669/
https://www.ncbi.nlm.nih.gov/pubmed/36674452
http://dx.doi.org/10.3390/ijms24020940
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