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Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy
West Nile virus (WNV) is a mosquito-borne virus potentially causing serious illness in humans and other animals. Since 2004, several studies have highlighted the progressive spread of WNV Lineage 2 (L2) in Europe, with Italy being one of the countries with the highest number of cases of West Nile di...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866873/ https://www.ncbi.nlm.nih.gov/pubmed/36680076 http://dx.doi.org/10.3390/v15010035 |
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author | Mencattelli, Giulia Silverj, Andrea Iapaolo, Federica Ippoliti, Carla Teodori, Liana Di Gennaro, Annapia Curini, Valentina Candeloro, Luca Conte, Annamaria Polci, Andrea Morelli, Daniela Perrotta, Maria Gabriella Marini, Giovanni Rosà, Roberto Monaco, Federica Segata, Nicola Rizzoli, Annapaola Rota-Stabelli, Omar Savini, Giovanni |
author_facet | Mencattelli, Giulia Silverj, Andrea Iapaolo, Federica Ippoliti, Carla Teodori, Liana Di Gennaro, Annapia Curini, Valentina Candeloro, Luca Conte, Annamaria Polci, Andrea Morelli, Daniela Perrotta, Maria Gabriella Marini, Giovanni Rosà, Roberto Monaco, Federica Segata, Nicola Rizzoli, Annapaola Rota-Stabelli, Omar Savini, Giovanni |
author_sort | Mencattelli, Giulia |
collection | PubMed |
description | West Nile virus (WNV) is a mosquito-borne virus potentially causing serious illness in humans and other animals. Since 2004, several studies have highlighted the progressive spread of WNV Lineage 2 (L2) in Europe, with Italy being one of the countries with the highest number of cases of West Nile disease reported. In this paper, we give an overview of the epidemiological and genetic features characterising the spread and evolution of WNV L2 in Italy, leveraging data obtained from national surveillance activities between 2011 and 2021, including 46 newly assembled genomes that were analysed under both phylogeographic and phylodynamic frameworks. In addition, to better understand the seasonal patterns of the virus, we used a machine learning model predicting areas at high-risk of WNV spread. Our results show a progressive increase in WNV L2 in Italy, clarifying the dynamics of interregional circulation, with no significant introductions from other countries in recent years. Moreover, the predicting model identified the presence of suitable conditions for the 2022 earlier and wider spread of WNV in Italy, underlining the importance of using quantitative models for early warning detection of WNV outbreaks. Taken together, these findings can be used as a reference to develop new strategies to mitigate the impact of the pathogen on human and other animal health in endemic areas and new regions. |
format | Online Article Text |
id | pubmed-9866873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98668732023-01-22 Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy Mencattelli, Giulia Silverj, Andrea Iapaolo, Federica Ippoliti, Carla Teodori, Liana Di Gennaro, Annapia Curini, Valentina Candeloro, Luca Conte, Annamaria Polci, Andrea Morelli, Daniela Perrotta, Maria Gabriella Marini, Giovanni Rosà, Roberto Monaco, Federica Segata, Nicola Rizzoli, Annapaola Rota-Stabelli, Omar Savini, Giovanni Viruses Article West Nile virus (WNV) is a mosquito-borne virus potentially causing serious illness in humans and other animals. Since 2004, several studies have highlighted the progressive spread of WNV Lineage 2 (L2) in Europe, with Italy being one of the countries with the highest number of cases of West Nile disease reported. In this paper, we give an overview of the epidemiological and genetic features characterising the spread and evolution of WNV L2 in Italy, leveraging data obtained from national surveillance activities between 2011 and 2021, including 46 newly assembled genomes that were analysed under both phylogeographic and phylodynamic frameworks. In addition, to better understand the seasonal patterns of the virus, we used a machine learning model predicting areas at high-risk of WNV spread. Our results show a progressive increase in WNV L2 in Italy, clarifying the dynamics of interregional circulation, with no significant introductions from other countries in recent years. Moreover, the predicting model identified the presence of suitable conditions for the 2022 earlier and wider spread of WNV in Italy, underlining the importance of using quantitative models for early warning detection of WNV outbreaks. Taken together, these findings can be used as a reference to develop new strategies to mitigate the impact of the pathogen on human and other animal health in endemic areas and new regions. MDPI 2022-12-22 /pmc/articles/PMC9866873/ /pubmed/36680076 http://dx.doi.org/10.3390/v15010035 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mencattelli, Giulia Silverj, Andrea Iapaolo, Federica Ippoliti, Carla Teodori, Liana Di Gennaro, Annapia Curini, Valentina Candeloro, Luca Conte, Annamaria Polci, Andrea Morelli, Daniela Perrotta, Maria Gabriella Marini, Giovanni Rosà, Roberto Monaco, Federica Segata, Nicola Rizzoli, Annapaola Rota-Stabelli, Omar Savini, Giovanni Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title | Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title_full | Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title_fullStr | Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title_full_unstemmed | Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title_short | Epidemiological and Evolutionary Analysis of West Nile Virus Lineage 2 in Italy |
title_sort | epidemiological and evolutionary analysis of west nile virus lineage 2 in italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866873/ https://www.ncbi.nlm.nih.gov/pubmed/36680076 http://dx.doi.org/10.3390/v15010035 |
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