The Role of NLRP3 Inflammasome in IgA Nephropathy

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, i...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofang, Zhao, Lei, Li, Kailong, Yang, Jurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866943/
https://www.ncbi.nlm.nih.gov/pubmed/36676706
http://dx.doi.org/10.3390/medicina59010082
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author Wu, Xiaofang
Zhao, Lei
Li, Kailong
Yang, Jurong
author_facet Wu, Xiaofang
Zhao, Lei
Li, Kailong
Yang, Jurong
author_sort Wu, Xiaofang
collection PubMed
description Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. This review focuses on the role of the NLRP3 inflammasome in IgAN and summarizes multiple involved pathways, which may provide novel treatments for IgAN treatment.
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spelling pubmed-98669432023-01-22 The Role of NLRP3 Inflammasome in IgA Nephropathy Wu, Xiaofang Zhao, Lei Li, Kailong Yang, Jurong Medicina (Kaunas) Review Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. This review focuses on the role of the NLRP3 inflammasome in IgAN and summarizes multiple involved pathways, which may provide novel treatments for IgAN treatment. MDPI 2022-12-30 /pmc/articles/PMC9866943/ /pubmed/36676706 http://dx.doi.org/10.3390/medicina59010082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Xiaofang
Zhao, Lei
Li, Kailong
Yang, Jurong
The Role of NLRP3 Inflammasome in IgA Nephropathy
title The Role of NLRP3 Inflammasome in IgA Nephropathy
title_full The Role of NLRP3 Inflammasome in IgA Nephropathy
title_fullStr The Role of NLRP3 Inflammasome in IgA Nephropathy
title_full_unstemmed The Role of NLRP3 Inflammasome in IgA Nephropathy
title_short The Role of NLRP3 Inflammasome in IgA Nephropathy
title_sort role of nlrp3 inflammasome in iga nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866943/
https://www.ncbi.nlm.nih.gov/pubmed/36676706
http://dx.doi.org/10.3390/medicina59010082
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