Cargando…
PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future †
With no expected vaccine for HIV in the near future, we aimed to define the current situation and challenges for pre- and post-exposure prophylaxis (PrEP and PEP) in Central and Eastern Europe (CEE). The Euroguidelines CEE Network Group members were invited to respond to a 27-item survey including q...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867039/ https://www.ncbi.nlm.nih.gov/pubmed/36679967 http://dx.doi.org/10.3390/vaccines11010122 |
_version_ | 1784876243178487808 |
---|---|
author | Gokengin, Deniz Bursa, Dominik Skrzat-Klapaczynska, Agata Alexiev, Ivailo Arsikj, Elena Balayan, Tatevik Begovac, Josip Cicic, Alma Dragovic, Gordana Harxhi, Arjan Aimla, Kerstin Lakatos, Botond Matulionyte, Raimonda Mulabdic, Velida Oprea, Cristiana Papadopoulos, Antonios Rukhadze, Nino Sedlacek, Dalibor Sojak, Lubomir Tomazic, Janez Vassilenko, Anna Vasylyev, Marta Verhaz, Antonija Yancheva, Nina Yurin, Oleg Kowalska, Justyna |
author_facet | Gokengin, Deniz Bursa, Dominik Skrzat-Klapaczynska, Agata Alexiev, Ivailo Arsikj, Elena Balayan, Tatevik Begovac, Josip Cicic, Alma Dragovic, Gordana Harxhi, Arjan Aimla, Kerstin Lakatos, Botond Matulionyte, Raimonda Mulabdic, Velida Oprea, Cristiana Papadopoulos, Antonios Rukhadze, Nino Sedlacek, Dalibor Sojak, Lubomir Tomazic, Janez Vassilenko, Anna Vasylyev, Marta Verhaz, Antonija Yancheva, Nina Yurin, Oleg Kowalska, Justyna |
author_sort | Gokengin, Deniz |
collection | PubMed |
description | With no expected vaccine for HIV in the near future, we aimed to define the current situation and challenges for pre- and post-exposure prophylaxis (PrEP and PEP) in Central and Eastern Europe (CEE). The Euroguidelines CEE Network Group members were invited to respond to a 27-item survey including questions on PrEP (response rate 91.6%). PrEP was licensed in 68.2%; 95 centers offered PrEP and the estimated number on PrEP was around 9000. It was available in daily (40.1%), on-demand (13.3%), or both forms (33.3%). The access rate was <1–80%. Three major barriers for access were lack of knowledge/awareness among people who are in need (59.1%), not being reimbursed (50.0%), and low perception of HIV risk (45.5%). Non-occupational PEP was available in 86.4% and was recommended in the guidelines in 54.5%. It was fully reimbursed in 36.4%, only for accidental exposures in 40.9%, and was not reimbursed in 22.72%. Occupational PEP was available in 95.5% and was reimbursed fully. Although PrEP scale-up in the region has gained momentum, a huge gap exists between those who are in need of and those who can access PrEP. Prompt action is required to address the urgent need for PrEP scale-up in the CEE region. |
format | Online Article Text |
id | pubmed-9867039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98670392023-01-22 PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † Gokengin, Deniz Bursa, Dominik Skrzat-Klapaczynska, Agata Alexiev, Ivailo Arsikj, Elena Balayan, Tatevik Begovac, Josip Cicic, Alma Dragovic, Gordana Harxhi, Arjan Aimla, Kerstin Lakatos, Botond Matulionyte, Raimonda Mulabdic, Velida Oprea, Cristiana Papadopoulos, Antonios Rukhadze, Nino Sedlacek, Dalibor Sojak, Lubomir Tomazic, Janez Vassilenko, Anna Vasylyev, Marta Verhaz, Antonija Yancheva, Nina Yurin, Oleg Kowalska, Justyna Vaccines (Basel) Article With no expected vaccine for HIV in the near future, we aimed to define the current situation and challenges for pre- and post-exposure prophylaxis (PrEP and PEP) in Central and Eastern Europe (CEE). The Euroguidelines CEE Network Group members were invited to respond to a 27-item survey including questions on PrEP (response rate 91.6%). PrEP was licensed in 68.2%; 95 centers offered PrEP and the estimated number on PrEP was around 9000. It was available in daily (40.1%), on-demand (13.3%), or both forms (33.3%). The access rate was <1–80%. Three major barriers for access were lack of knowledge/awareness among people who are in need (59.1%), not being reimbursed (50.0%), and low perception of HIV risk (45.5%). Non-occupational PEP was available in 86.4% and was recommended in the guidelines in 54.5%. It was fully reimbursed in 36.4%, only for accidental exposures in 40.9%, and was not reimbursed in 22.72%. Occupational PEP was available in 95.5% and was reimbursed fully. Although PrEP scale-up in the region has gained momentum, a huge gap exists between those who are in need of and those who can access PrEP. Prompt action is required to address the urgent need for PrEP scale-up in the CEE region. MDPI 2023-01-04 /pmc/articles/PMC9867039/ /pubmed/36679967 http://dx.doi.org/10.3390/vaccines11010122 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gokengin, Deniz Bursa, Dominik Skrzat-Klapaczynska, Agata Alexiev, Ivailo Arsikj, Elena Balayan, Tatevik Begovac, Josip Cicic, Alma Dragovic, Gordana Harxhi, Arjan Aimla, Kerstin Lakatos, Botond Matulionyte, Raimonda Mulabdic, Velida Oprea, Cristiana Papadopoulos, Antonios Rukhadze, Nino Sedlacek, Dalibor Sojak, Lubomir Tomazic, Janez Vassilenko, Anna Vasylyev, Marta Verhaz, Antonija Yancheva, Nina Yurin, Oleg Kowalska, Justyna PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title | PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title_full | PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title_fullStr | PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title_full_unstemmed | PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title_short | PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future † |
title_sort | prep scale-up and pep in central and eastern europe: changes in time and the challenges we face with no expected hiv vaccine in the near future † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867039/ https://www.ncbi.nlm.nih.gov/pubmed/36679967 http://dx.doi.org/10.3390/vaccines11010122 |
work_keys_str_mv | AT gokengindeniz prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT bursadominik prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT skrzatklapaczynskaagata prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT alexievivailo prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT arsikjelena prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT balayantatevik prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT begovacjosip prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT cicicalma prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT dragovicgordana prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT harxhiarjan prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT aimlakerstin prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT lakatosbotond prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT matulionyteraimonda prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT mulabdicvelida prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT opreacristiana prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT papadopoulosantonios prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT rukhadzenino prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT sedlacekdalibor prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT sojaklubomir prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT tomazicjanez prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT vassilenkoanna prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT vasylyevmarta prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT verhazantonija prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT yanchevanina prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT yurinoleg prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture AT kowalskajustyna prepscaleupandpepincentralandeasterneuropechangesintimeandthechallengeswefacewithnoexpectedhivvaccineinthenearfuture |