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Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study

Introduction. Studies suggest that people with multiple sclerosis (pwMS) experience continuous and subclinical physical worsening, even as early as their disease diagnosis. Validating sensitive and reproducible tests that can capture subclinical disease activity early in the disease are clinically u...

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Autores principales: Glavor, Klaudia Duka, Weinstock-Guttman, Bianca, Vuletić, Gorka, Vranić Ivanac, Iva, Šimić, Nataša, Covey, Thomas J., Jakimovski, Dejan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867060/
https://www.ncbi.nlm.nih.gov/pubmed/36676653
http://dx.doi.org/10.3390/medicina59010029
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author Glavor, Klaudia Duka
Weinstock-Guttman, Bianca
Vuletić, Gorka
Vranić Ivanac, Iva
Šimić, Nataša
Covey, Thomas J.
Jakimovski, Dejan
author_facet Glavor, Klaudia Duka
Weinstock-Guttman, Bianca
Vuletić, Gorka
Vranić Ivanac, Iva
Šimić, Nataša
Covey, Thomas J.
Jakimovski, Dejan
author_sort Glavor, Klaudia Duka
collection PubMed
description Introduction. Studies suggest that people with multiple sclerosis (pwMS) experience continuous and subclinical physical worsening, even as early as their disease diagnosis. Validating sensitive and reproducible tests that can capture subclinical disease activity early in the disease are clinically useful and highly warranted. We aimed at validating the utility of Fitts’ Tapping Task (FTT) as reproducible measure of psychomotor performance in pwMS. Materials and Methods. Thirty newly-diagnosed pwMS (within 2 years of diagnosis and Expanded Disability Status Scale; EDSS ≤ 2.0), 30 people with migraine (pwMig), and 30 healthy controls (HCs) underwent a psychomotor assessment using the FTT, O’Connor hand dexterity test, and Visual Reaction Time Test (VRTT). Hand strength was measured using a hand-grip dynamometer. Subjects also provided patient-reported outcomes (PROs) using the 36-Item Short Form Survey (SF-36). Intrarater and interrater reproducibility was acquired on 5 HCs by two independent operators. Test–retest reproducibility was determined in 5 pwMS over a 1-week follow-up. Eight pwMS returned for the same test procedures 2 years after the baseline assessment. Bland–Altman plots were used to determine the minimally detectable change (MDC) and logistic regression models determined the ability to differentiate between newly-diagnosed pwMS and HCs. Results. FTT exhibited a high intrarater and interrater reproducibility (interclass correlation coefficient of 0.961, p < 0.001). The test–retest demonstrated an MDC of the average FTT at > 15%. PwMS had significantly a slower FTT time and O’Connor dexterity time when compared to pwMig and HCs (p < 0.001 for both). Higher Fitts’ difficulty levels (4th and 6th difficulty) and average performance on the O’Connor test were able to differentiate newly-diagnosed pwMS from HCs with 80% accuracy (p < 0.01). Slower FTT performance was correlated with worse PROs due to physical health. Over the 2-year follow-up, and despite being clinically stable (no change in EDSS), 6 out of 8 (75%) pwMS had more than a 15% worsening in their average FTT time. Conclusions. FTT is a highly-reproducible test for measuring psychomotor performance in newly-diagnosed pwMS. FTT can capture insidious worsening in psychomotor performance and cognitive function in early stages of MS.
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spelling pubmed-98670602023-01-22 Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study Glavor, Klaudia Duka Weinstock-Guttman, Bianca Vuletić, Gorka Vranić Ivanac, Iva Šimić, Nataša Covey, Thomas J. Jakimovski, Dejan Medicina (Kaunas) Article Introduction. Studies suggest that people with multiple sclerosis (pwMS) experience continuous and subclinical physical worsening, even as early as their disease diagnosis. Validating sensitive and reproducible tests that can capture subclinical disease activity early in the disease are clinically useful and highly warranted. We aimed at validating the utility of Fitts’ Tapping Task (FTT) as reproducible measure of psychomotor performance in pwMS. Materials and Methods. Thirty newly-diagnosed pwMS (within 2 years of diagnosis and Expanded Disability Status Scale; EDSS ≤ 2.0), 30 people with migraine (pwMig), and 30 healthy controls (HCs) underwent a psychomotor assessment using the FTT, O’Connor hand dexterity test, and Visual Reaction Time Test (VRTT). Hand strength was measured using a hand-grip dynamometer. Subjects also provided patient-reported outcomes (PROs) using the 36-Item Short Form Survey (SF-36). Intrarater and interrater reproducibility was acquired on 5 HCs by two independent operators. Test–retest reproducibility was determined in 5 pwMS over a 1-week follow-up. Eight pwMS returned for the same test procedures 2 years after the baseline assessment. Bland–Altman plots were used to determine the minimally detectable change (MDC) and logistic regression models determined the ability to differentiate between newly-diagnosed pwMS and HCs. Results. FTT exhibited a high intrarater and interrater reproducibility (interclass correlation coefficient of 0.961, p < 0.001). The test–retest demonstrated an MDC of the average FTT at > 15%. PwMS had significantly a slower FTT time and O’Connor dexterity time when compared to pwMig and HCs (p < 0.001 for both). Higher Fitts’ difficulty levels (4th and 6th difficulty) and average performance on the O’Connor test were able to differentiate newly-diagnosed pwMS from HCs with 80% accuracy (p < 0.01). Slower FTT performance was correlated with worse PROs due to physical health. Over the 2-year follow-up, and despite being clinically stable (no change in EDSS), 6 out of 8 (75%) pwMS had more than a 15% worsening in their average FTT time. Conclusions. FTT is a highly-reproducible test for measuring psychomotor performance in newly-diagnosed pwMS. FTT can capture insidious worsening in psychomotor performance and cognitive function in early stages of MS. MDPI 2022-12-23 /pmc/articles/PMC9867060/ /pubmed/36676653 http://dx.doi.org/10.3390/medicina59010029 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glavor, Klaudia Duka
Weinstock-Guttman, Bianca
Vuletić, Gorka
Vranić Ivanac, Iva
Šimić, Nataša
Covey, Thomas J.
Jakimovski, Dejan
Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title_full Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title_fullStr Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title_full_unstemmed Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title_short Fitts’ Tapping Task as a New Test for Cognition and Manual Dexterity in Multiple Sclerosis: Validation Study
title_sort fitts’ tapping task as a new test for cognition and manual dexterity in multiple sclerosis: validation study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867060/
https://www.ncbi.nlm.nih.gov/pubmed/36676653
http://dx.doi.org/10.3390/medicina59010029
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