Cargando…

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hendawy, Omnia M., Al-Sanea, Mohammad M., Elbargisy, Rehab M., Rahman, Hidayat Ur, Mohamed, Ahmed A. B., Kamal, Islam, Elshaarawy, Reda F. M., Khedr, Amgad I. M., El-Fattah, Wesam Abd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867062/
https://www.ncbi.nlm.nih.gov/pubmed/36678711
http://dx.doi.org/10.3390/pharmaceutics15010081
_version_ 1784876249007521792
author Hendawy, Omnia M.
Al-Sanea, Mohammad M.
Elbargisy, Rehab M.
Rahman, Hidayat Ur
Mohamed, Ahmed A. B.
Kamal, Islam
Elshaarawy, Reda F. M.
Khedr, Amgad I. M.
El-Fattah, Wesam Abd
author_facet Hendawy, Omnia M.
Al-Sanea, Mohammad M.
Elbargisy, Rehab M.
Rahman, Hidayat Ur
Mohamed, Ahmed A. B.
Kamal, Islam
Elshaarawy, Reda F. M.
Khedr, Amgad I. M.
El-Fattah, Wesam Abd
author_sort Hendawy, Omnia M.
collection PubMed
description Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order to upgrade the pharmaceutical capabilities of VOO and HT, a new conjugate phenylboronic acid-chitosan nanoparticles (PBA-CSNPs, NF-1) was fabricated and applied as nanocapsules for implanting high loading and efficient delivery of VOO and HT nanoformulations (NF-2 and NF-3). Due to the H-bonding interactions and boronate ester formation between the hydroxyl groups of the phenolic content of VOO or HT and the PBA groups in the nanocapsules (NF-1), VOO and HT were successfully loaded into the PBA-CSNPs nanocapsules with high loading contents and encapsulation efficacies. The NF-2 and NF-3 nanoformulations demonstrated physicochemical stability, as revealed by their respective zeta potential values, and pH-triggered drug release characteristics. The in vitro studies demonstrated that the nascent nanocapsules were almost completely nontoxic to both healthy and cancer cells, whereas VOO-loaded (NF-2) and HT-loaded nanocapsules (NF-3) showed efficient anti-breast cancer efficiencies. In addition, the antimicrobial and antioxidant potentials of VOO and HT were significantly improved after nanoencapsulation.
format Online
Article
Text
id pubmed-9867062
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98670622023-01-22 Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol Hendawy, Omnia M. Al-Sanea, Mohammad M. Elbargisy, Rehab M. Rahman, Hidayat Ur Mohamed, Ahmed A. B. Kamal, Islam Elshaarawy, Reda F. M. Khedr, Amgad I. M. El-Fattah, Wesam Abd Pharmaceutics Article Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order to upgrade the pharmaceutical capabilities of VOO and HT, a new conjugate phenylboronic acid-chitosan nanoparticles (PBA-CSNPs, NF-1) was fabricated and applied as nanocapsules for implanting high loading and efficient delivery of VOO and HT nanoformulations (NF-2 and NF-3). Due to the H-bonding interactions and boronate ester formation between the hydroxyl groups of the phenolic content of VOO or HT and the PBA groups in the nanocapsules (NF-1), VOO and HT were successfully loaded into the PBA-CSNPs nanocapsules with high loading contents and encapsulation efficacies. The NF-2 and NF-3 nanoformulations demonstrated physicochemical stability, as revealed by their respective zeta potential values, and pH-triggered drug release characteristics. The in vitro studies demonstrated that the nascent nanocapsules were almost completely nontoxic to both healthy and cancer cells, whereas VOO-loaded (NF-2) and HT-loaded nanocapsules (NF-3) showed efficient anti-breast cancer efficiencies. In addition, the antimicrobial and antioxidant potentials of VOO and HT were significantly improved after nanoencapsulation. MDPI 2022-12-27 /pmc/articles/PMC9867062/ /pubmed/36678711 http://dx.doi.org/10.3390/pharmaceutics15010081 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hendawy, Omnia M.
Al-Sanea, Mohammad M.
Elbargisy, Rehab M.
Rahman, Hidayat Ur
Mohamed, Ahmed A. B.
Kamal, Islam
Elshaarawy, Reda F. M.
Khedr, Amgad I. M.
El-Fattah, Wesam Abd
Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title_full Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title_fullStr Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title_full_unstemmed Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title_short Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol
title_sort phenylboronic acid-grafted chitosan nanocapsules for effective delivery and controllable release of natural antioxidants: olive oil and hydroxytyrosol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867062/
https://www.ncbi.nlm.nih.gov/pubmed/36678711
http://dx.doi.org/10.3390/pharmaceutics15010081
work_keys_str_mv AT hendawyomniam phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT alsaneamohammadm phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT elbargisyrehabm phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT rahmanhidayatur phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT mohamedahmedab phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT kamalislam phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT elshaarawyredafm phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT khedramgadim phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol
AT elfattahwesamabd phenylboronicacidgraftedchitosannanocapsulesforeffectivedeliveryandcontrollablereleaseofnaturalantioxidantsoliveoilandhydroxytyrosol