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Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint

The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammator...

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Autores principales: Emran, Talha Bin, Islam, Fahadul, Nath, Nikhil, Sutradhar, Hriday, Das, Rajib, Mitra, Saikat, Alshahrani, Mohammed Merae, Alhasaniah, Abdulaziz Hassan, Sharma, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867091/
https://www.ncbi.nlm.nih.gov/pubmed/36676048
http://dx.doi.org/10.3390/life13010099
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author Emran, Talha Bin
Islam, Fahadul
Nath, Nikhil
Sutradhar, Hriday
Das, Rajib
Mitra, Saikat
Alshahrani, Mohammed Merae
Alhasaniah, Abdulaziz Hassan
Sharma, Rohit
author_facet Emran, Talha Bin
Islam, Fahadul
Nath, Nikhil
Sutradhar, Hriday
Das, Rajib
Mitra, Saikat
Alshahrani, Mohammed Merae
Alhasaniah, Abdulaziz Hassan
Sharma, Rohit
author_sort Emran, Talha Bin
collection PubMed
description The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods.
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spelling pubmed-98670912023-01-22 Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint Emran, Talha Bin Islam, Fahadul Nath, Nikhil Sutradhar, Hriday Das, Rajib Mitra, Saikat Alshahrani, Mohammed Merae Alhasaniah, Abdulaziz Hassan Sharma, Rohit Life (Basel) Review The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods. MDPI 2022-12-29 /pmc/articles/PMC9867091/ /pubmed/36676048 http://dx.doi.org/10.3390/life13010099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Emran, Talha Bin
Islam, Fahadul
Nath, Nikhil
Sutradhar, Hriday
Das, Rajib
Mitra, Saikat
Alshahrani, Mohammed Merae
Alhasaniah, Abdulaziz Hassan
Sharma, Rohit
Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title_full Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title_fullStr Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title_full_unstemmed Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title_short Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
title_sort naringin and naringenin polyphenols in neurological diseases: understandings from a therapeutic viewpoint
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867091/
https://www.ncbi.nlm.nih.gov/pubmed/36676048
http://dx.doi.org/10.3390/life13010099
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