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Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy

The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and qua...

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Detalles Bibliográficos
Autores principales: Costa, Bárbara, Vale, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867121/
https://www.ncbi.nlm.nih.gov/pubmed/36678799
http://dx.doi.org/10.3390/pharmaceutics15010167
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author Costa, Bárbara
Vale, Nuno
author_facet Costa, Bárbara
Vale, Nuno
author_sort Costa, Bárbara
collection PubMed
description The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and quantitative forecasts that may be used to follow the immune system and create a disease profile for each patient, mathematical models are helpful in characterizing these non-linear interactions. To increase our ability to treat patients and identify individual differences in disease development, immune response profiling might be useful. Identifying which patients are moving from mild to severe disease would be more beneficial using immune system parameters. Prioritize treatments based on their inability to control the immune response and prevent T cell exhaustion. To increase treatment efficacy and spur additional research in this field, this review intends to provide examples of the effects of modelling immune response in viral infections, as well as the impact of pharmaceuticals on immune response.
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spelling pubmed-98671212023-01-22 Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy Costa, Bárbara Vale, Nuno Pharmaceutics Review The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and quantitative forecasts that may be used to follow the immune system and create a disease profile for each patient, mathematical models are helpful in characterizing these non-linear interactions. To increase our ability to treat patients and identify individual differences in disease development, immune response profiling might be useful. Identifying which patients are moving from mild to severe disease would be more beneficial using immune system parameters. Prioritize treatments based on their inability to control the immune response and prevent T cell exhaustion. To increase treatment efficacy and spur additional research in this field, this review intends to provide examples of the effects of modelling immune response in viral infections, as well as the impact of pharmaceuticals on immune response. MDPI 2023-01-03 /pmc/articles/PMC9867121/ /pubmed/36678799 http://dx.doi.org/10.3390/pharmaceutics15010167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Costa, Bárbara
Vale, Nuno
Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title_full Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title_fullStr Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title_full_unstemmed Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title_short Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
title_sort modulating immune response in viral infection for quantitative forecasts of drug efficacy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867121/
https://www.ncbi.nlm.nih.gov/pubmed/36678799
http://dx.doi.org/10.3390/pharmaceutics15010167
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