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Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy
The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and qua...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867121/ https://www.ncbi.nlm.nih.gov/pubmed/36678799 http://dx.doi.org/10.3390/pharmaceutics15010167 |
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author | Costa, Bárbara Vale, Nuno |
author_facet | Costa, Bárbara Vale, Nuno |
author_sort | Costa, Bárbara |
collection | PubMed |
description | The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and quantitative forecasts that may be used to follow the immune system and create a disease profile for each patient, mathematical models are helpful in characterizing these non-linear interactions. To increase our ability to treat patients and identify individual differences in disease development, immune response profiling might be useful. Identifying which patients are moving from mild to severe disease would be more beneficial using immune system parameters. Prioritize treatments based on their inability to control the immune response and prevent T cell exhaustion. To increase treatment efficacy and spur additional research in this field, this review intends to provide examples of the effects of modelling immune response in viral infections, as well as the impact of pharmaceuticals on immune response. |
format | Online Article Text |
id | pubmed-9867121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98671212023-01-22 Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy Costa, Bárbara Vale, Nuno Pharmaceutics Review The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and quantitative forecasts that may be used to follow the immune system and create a disease profile for each patient, mathematical models are helpful in characterizing these non-linear interactions. To increase our ability to treat patients and identify individual differences in disease development, immune response profiling might be useful. Identifying which patients are moving from mild to severe disease would be more beneficial using immune system parameters. Prioritize treatments based on their inability to control the immune response and prevent T cell exhaustion. To increase treatment efficacy and spur additional research in this field, this review intends to provide examples of the effects of modelling immune response in viral infections, as well as the impact of pharmaceuticals on immune response. MDPI 2023-01-03 /pmc/articles/PMC9867121/ /pubmed/36678799 http://dx.doi.org/10.3390/pharmaceutics15010167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Costa, Bárbara Vale, Nuno Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title | Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title_full | Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title_fullStr | Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title_full_unstemmed | Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title_short | Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy |
title_sort | modulating immune response in viral infection for quantitative forecasts of drug efficacy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867121/ https://www.ncbi.nlm.nih.gov/pubmed/36678799 http://dx.doi.org/10.3390/pharmaceutics15010167 |
work_keys_str_mv | AT costabarbara modulatingimmuneresponseinviralinfectionforquantitativeforecastsofdrugefficacy AT valenuno modulatingimmuneresponseinviralinfectionforquantitativeforecastsofdrugefficacy |