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Anti-HIV Potential of Beesioside I Derivatives as Maturation Inhibitors: Synthesis, 3D-QSAR, Molecular Docking and Molecular Dynamics Simulations

HIV-1 maturation is the final step in the retroviral lifecycle that is regulated by the proteolytic cleavage of the Gag precursor protein. As a first-in-class HIV-1 maturation inhibitor (MI), bevirimat blocks virion maturation by disrupting capsid-spacer peptide 1 (CA-SP1) cleavage, which acts as th...

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Detalles Bibliográficos
Autores principales:	Zhao, Zixuan, Ma, Yinghong, Li, Xiangyuan, Morris-Natschke, Susan L., Sun, Zhaocui, Sun, Zhonghao, Ma, Guoxu, Dong, Zhengqi, Zhao, Xiaohong, Yang, Meihua, Xu, Xudong, Lee, Kuohsiung, Wu, Haifeng, Chen, Chinho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867151/ https://www.ncbi.nlm.nih.gov/pubmed/36674943 http://dx.doi.org/10.3390/ijms24021430

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