Cargando…

Ageing Curtails the Diversity and Functionality of Nascent CD8(+) T Cell Responses against SARS-CoV-2

Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated in vitro approach to determine how age impacts the generation of de novo CD8(+)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Proietto, Davide, Dallan, Beatrice, Gallerani, Eleonora, Albanese, Valentina, Llewellyn-Lacey, Sian, Price, David A., Appay, Victor, Pacifico, Salvatore, Caputo, Antonella, Nicoli, Francesco, Gavioli, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867380/ https://www.ncbi.nlm.nih.gov/pubmed/36679999 http://dx.doi.org/10.3390/vaccines11010154

Ejemplares similares

Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects
por: Gallerani, Eleonora, et al.
Publicado: (2021)

Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines
por: Nicoli, Francesco, et al.
Publicado: (2021)

The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation
por: Nicoli, Francesco, et al.
Publicado: (2020)

Altered basal lipid metabolism underlies the functional impairment of naive CD8(+) T cells in elderly humans
por: Nicoli, Francesco, et al.
Publicado: (2022)

The HIV-1 Tat Protein Induces the Activation of CD8(+) T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses
por: Nicoli, Francesco, et al.
Publicado: (2013)

Effects of the age of vaccination on the humoral responses to a human papillomavirus vaccine
por: Nicoli, Francesco, et al.
Publicado: (2022)

Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity
por: Nicoli, Francesco, et al.
Publicado: (2020)

HPV-Specific Systemic Antibody Responses and Memory B Cells are Independently Maintained up to 6 Years and in a Vaccine-Specific Manner Following Immunization with Cervarix and Gardasil in Adolescent and Young Adult Women in Vaccination Programs in Italy
por: Nicoli, Francesco, et al.
Publicado: (2020)

An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge
por: Sicurella, Mariaconcetta, et al.
Publicado: (2014)

Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice
por: Cellini, Silvia, et al.
Publicado: (2008)

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4 (+) and CD8 (+) T cells
por: Zurlo, Matteo, et al.
Publicado: (2023)

Curtailing infection
por: Williams, Ruth
Publicado: (2006)

Naïve CD8(+) T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8(+) T-Cells
por: Nicoli, Francesco, et al.
Publicado: (2018)

Focus group study on perceptions and information needs regarding vaccines targeting the older population: a cross-country comparison in four European countries
por: Wennekes, Manuela Dominique, et al.
Publicado: (2022)

Harnessing the Induction of CD8(+) T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting Cells
por: Nicoli, Francesco, et al.
Publicado: (2018)

Curtailing the collapse of the living world
por: Naeem, Shahid, et al.
Publicado: (2022)

Immunotherapeutic approaches to curtail COVID-19
por: Owji, Hajar, et al.
Publicado: (2020)

Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model
por: Di Benedetto, Giulia, et al.
Publicado: (2019)

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8(+) T-cell responses in vitro
por: Papagno, Laura, et al.
Publicado: (2020)

Public health measures to curtail infant mortality
por: Shrivastava, Saurabh RamBihariLal, et al.
Publicado: (2014)

Curtailment of Civil Liberties and Subjective Life Satisfaction
por: Windsteiger, Lisa, et al.
Publicado: (2021)

Asexualization for the Prevention of Crime and the Curtailment of the Propagation of Criminals
por: Sim, F. L.
Publicado: (1894)

Entrepreneurial metacognition: a study on nascent entrepreneurs
por: Bastian, Bob, et al.
Publicado: (2022)

Rational Design of Nucleoside–Bile Acid Conjugates Incorporating a Triazole Moiety for Anticancer Evaluation and SAR Exploration
por: Navacchia, Maria Luisa, et al.
Publicado: (2017)

Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors
por: Marastoni, Mauro, et al.
Publicado: (2017)

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
por: Ottina, Eleonora, et al.
Publicado: (2017)

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8(+) T cells in HIV infection
por: Cabral-Piccin, Mariela P., et al.
Publicado: (2023)

Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents
por: Barbari, Riccardo, et al.
Publicado: (2022)

Lassa fever: the challenges of curtailing a deadly disease
por: Ibekwe, Titus
Publicado: (2012)

Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
por: Lucassen, Eliane A, et al.
Publicado: (2012)

Evaluating the effectiveness of localized control strategies to curtail chikungunya
por: Ndeffo-Mbah, Martial L., et al.
Publicado: (2016)

Will an imperfect vaccine curtail the COVID-19 pandemic in the U.S.?
por: Iboi, Enahoro A., et al.
Publicado: (2020)

The importance of wearing masks in curtailing the COVID-19 pandemic
por: Humphreys, Jose
Publicado: (2020)

Extraordinary curtailment of massive typhus epidemic in the Warsaw Ghetto
por: Stone, Lewi, et al.
Publicado: (2020)

Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma
por: Russignan, Anna, et al.
Publicado: (2021)

Complete but curtailed T cell response to very low affinity antigen
por: Zehn, Dietmar, et al.
Publicado: (2009)

Fluid curtailment during childhood diarrhea: a countdown analysis
por: Perin, Jamie, et al.
Publicado: (2015)

Longitudinal Associations of Sleep Curtailment with Metabolic Risk in Mid-Childhood
por: Cespedes, Elizabeth M., et al.
Publicado: (2014)

The Effect of Sleep Curtailment on Hedonic Responses to Liquid and Solid Food
por: Szczygiel, Edward J., et al.
Publicado: (2019)

The imperative for universal healthcare to curtail the COVID-19 outbreak in the USA
por: Galvani, Alison P., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r4a12m45jeloc0mnc4pjbo0775