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Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization

The purpose of the paper is to describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern. It is a retrospective study of patients who were investigated for C...

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Autores principales: Pagano, Luca, Shah, Haider, Gadhvi, Kunal, Ahmad, Mohammad, Menassa, Nardine, Coco, Giulia, Kaye, Stephen, Romano, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867460/
https://www.ncbi.nlm.nih.gov/pubmed/36675562
http://dx.doi.org/10.3390/jcm12020633
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author Pagano, Luca
Shah, Haider
Gadhvi, Kunal
Ahmad, Mohammad
Menassa, Nardine
Coco, Giulia
Kaye, Stephen
Romano, Vito
author_facet Pagano, Luca
Shah, Haider
Gadhvi, Kunal
Ahmad, Mohammad
Menassa, Nardine
Coco, Giulia
Kaye, Stephen
Romano, Vito
author_sort Pagano, Luca
collection PubMed
description The purpose of the paper is to describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern. It is a retrospective study of patients who were investigated for CoNV using fluorescein angiography (FA) or indocyanine green angiography (ICGA) between January 2010 and July 2020. Angiography images were graded and analyzed multiple independent corneal specialists. The corneal surface was divided into four quadrants and patient information was obtained through electronic records. A total of 133 eyes were analyzed. Corneal lesions were located on the peripheral (72%) or central (28%) cornea. Central lesions were associated with multi-quadrant CoNV more frequently than peripheral lesions (p = 0.15). CoNV located within the same quadrant of the corneal lesion was often first to fill (88.4%). In multi-quadrant CoNV, the physiological inferior–superior–nasal–temporal order of filling was usually respected (61.7%). Central lesions resulted in larger CoNV surface area than peripheral lesions (p = 0.09). In multi-quadrant CoNV, the largest area of neovascularization was also the first to fill in (peripheral lesion 74%, central lesion 65%). Fillings patterns in healthy corneas have previously been reported. Despite CoNV development, these patterns are usually respected. Several factors that may influence filling patterns have been identified, including corneal lesion location, CoNV surface area and aetiology of CoNV. Understanding filling patterns of neovascularization allows for the identification of areas at higher risk of developing CoNV, aiding in earlier detection and intervention of CoNV.
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spelling pubmed-98674602023-01-22 Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization Pagano, Luca Shah, Haider Gadhvi, Kunal Ahmad, Mohammad Menassa, Nardine Coco, Giulia Kaye, Stephen Romano, Vito J Clin Med Article The purpose of the paper is to describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern. It is a retrospective study of patients who were investigated for CoNV using fluorescein angiography (FA) or indocyanine green angiography (ICGA) between January 2010 and July 2020. Angiography images were graded and analyzed multiple independent corneal specialists. The corneal surface was divided into four quadrants and patient information was obtained through electronic records. A total of 133 eyes were analyzed. Corneal lesions were located on the peripheral (72%) or central (28%) cornea. Central lesions were associated with multi-quadrant CoNV more frequently than peripheral lesions (p = 0.15). CoNV located within the same quadrant of the corneal lesion was often first to fill (88.4%). In multi-quadrant CoNV, the physiological inferior–superior–nasal–temporal order of filling was usually respected (61.7%). Central lesions resulted in larger CoNV surface area than peripheral lesions (p = 0.09). In multi-quadrant CoNV, the largest area of neovascularization was also the first to fill in (peripheral lesion 74%, central lesion 65%). Fillings patterns in healthy corneas have previously been reported. Despite CoNV development, these patterns are usually respected. Several factors that may influence filling patterns have been identified, including corneal lesion location, CoNV surface area and aetiology of CoNV. Understanding filling patterns of neovascularization allows for the identification of areas at higher risk of developing CoNV, aiding in earlier detection and intervention of CoNV. MDPI 2023-01-12 /pmc/articles/PMC9867460/ /pubmed/36675562 http://dx.doi.org/10.3390/jcm12020633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pagano, Luca
Shah, Haider
Gadhvi, Kunal
Ahmad, Mohammad
Menassa, Nardine
Coco, Giulia
Kaye, Stephen
Romano, Vito
Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title_full Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title_fullStr Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title_full_unstemmed Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title_short Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
title_sort assessment of corneal angiography filling patterns in corneal neovascularization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867460/
https://www.ncbi.nlm.nih.gov/pubmed/36675562
http://dx.doi.org/10.3390/jcm12020633
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