ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN

Neuroblastoma (NB) is characterized by several malignant phenotypes that are difficult to treat effectively without combination therapy. The therapeutic implication of mitochondrial ClpXP protease ClpP and ClpX has been verified in several malignancies, but is unknown in NB. Firstly, we observed a s...

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Detalles Bibliográficos
Autores principales: Wu, Jian-Ching, Huang, Chao-Cheng, Wang, Pei-Wen, Chen, Ting-Ya, Hsu, Wen-Ming, Chuang, Jiin-Haur, Chuang, Hui-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867473/
https://www.ncbi.nlm.nih.gov/pubmed/36675163
http://dx.doi.org/10.3390/ijms24021649

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