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Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development
Pre-clinical models and clinical studies highlight the significant impact of the host–microbiota relationship on cancer development and treatment, supporting the emerging trend for a microbiota-based approach in clinical oncology. Importantly, the presence of polymorphic microbes is considered one o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867529/ https://www.ncbi.nlm.nih.gov/pubmed/36677399 http://dx.doi.org/10.3390/microorganisms11010107 |
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author | Nikolaieva, Nataliia Sevcikova, Aneta Omelka, Radoslav Martiniakova, Monika Mego, Michal Ciernikova, Sona |
author_facet | Nikolaieva, Nataliia Sevcikova, Aneta Omelka, Radoslav Martiniakova, Monika Mego, Michal Ciernikova, Sona |
author_sort | Nikolaieva, Nataliia |
collection | PubMed |
description | Pre-clinical models and clinical studies highlight the significant impact of the host–microbiota relationship on cancer development and treatment, supporting the emerging trend for a microbiota-based approach in clinical oncology. Importantly, the presence of polymorphic microbes is considered one of the hallmarks of cancer. The epigenetic regulation of gene expression by microRNAs affects crucial biological processes, including proliferation, differentiation, metabolism, and cell death. Recent evidence has documented the existence of bidirectional gut microbiota–microRNA interactions that play a critical role in intestinal homeostasis. Importantly, alterations in microRNA-modulated gene expression are known to be associated with inflammatory responses and dysbiosis in gastrointestinal disorders. In this review, we summarize the current findings about miRNA expression in the intestine and focus on specific gut microbiota–miRNA interactions linked to intestinal homeostasis, the immune system, and cancer development. We discuss the potential clinical utility of fecal miRNA profiling as a diagnostic and prognostic tool in colorectal cancer, and demonstrate how the emerging trend of gut microbiota modulation, together with the use of personalized microRNA therapeutics, might bring improvements in outcomes for patients with gastrointestinal cancer in the era of precision medicine. |
format | Online Article Text |
id | pubmed-9867529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98675292023-01-22 Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development Nikolaieva, Nataliia Sevcikova, Aneta Omelka, Radoslav Martiniakova, Monika Mego, Michal Ciernikova, Sona Microorganisms Review Pre-clinical models and clinical studies highlight the significant impact of the host–microbiota relationship on cancer development and treatment, supporting the emerging trend for a microbiota-based approach in clinical oncology. Importantly, the presence of polymorphic microbes is considered one of the hallmarks of cancer. The epigenetic regulation of gene expression by microRNAs affects crucial biological processes, including proliferation, differentiation, metabolism, and cell death. Recent evidence has documented the existence of bidirectional gut microbiota–microRNA interactions that play a critical role in intestinal homeostasis. Importantly, alterations in microRNA-modulated gene expression are known to be associated with inflammatory responses and dysbiosis in gastrointestinal disorders. In this review, we summarize the current findings about miRNA expression in the intestine and focus on specific gut microbiota–miRNA interactions linked to intestinal homeostasis, the immune system, and cancer development. We discuss the potential clinical utility of fecal miRNA profiling as a diagnostic and prognostic tool in colorectal cancer, and demonstrate how the emerging trend of gut microbiota modulation, together with the use of personalized microRNA therapeutics, might bring improvements in outcomes for patients with gastrointestinal cancer in the era of precision medicine. MDPI 2022-12-31 /pmc/articles/PMC9867529/ /pubmed/36677399 http://dx.doi.org/10.3390/microorganisms11010107 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nikolaieva, Nataliia Sevcikova, Aneta Omelka, Radoslav Martiniakova, Monika Mego, Michal Ciernikova, Sona Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title | Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title_full | Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title_fullStr | Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title_full_unstemmed | Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title_short | Gut Microbiota–MicroRNA Interactions in Intestinal Homeostasis and Cancer Development |
title_sort | gut microbiota–microrna interactions in intestinal homeostasis and cancer development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867529/ https://www.ncbi.nlm.nih.gov/pubmed/36677399 http://dx.doi.org/10.3390/microorganisms11010107 |
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