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Biomarkers in Child and Adolescent Depression
Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867683/ https://www.ncbi.nlm.nih.gov/pubmed/34590201 http://dx.doi.org/10.1007/s10578-021-01246-y |
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author | Zwolińska, Weronika Dmitrzak-Węglarz, Monika Słopień, Agnieszka |
author_facet | Zwolińska, Weronika Dmitrzak-Węglarz, Monika Słopień, Agnieszka |
author_sort | Zwolińska, Weronika |
collection | PubMed |
description | Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future directions in the research on this subject. More studies on depression involving the youth population seem vital to comprehend the natural course of the disease and identify features that may underlie commonly observed differences in treatment outcomes between adults and children. |
format | Online Article Text |
id | pubmed-9867683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-98676832023-01-23 Biomarkers in Child and Adolescent Depression Zwolińska, Weronika Dmitrzak-Węglarz, Monika Słopień, Agnieszka Child Psychiatry Hum Dev Article Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future directions in the research on this subject. More studies on depression involving the youth population seem vital to comprehend the natural course of the disease and identify features that may underlie commonly observed differences in treatment outcomes between adults and children. Springer US 2021-09-29 2023 /pmc/articles/PMC9867683/ /pubmed/34590201 http://dx.doi.org/10.1007/s10578-021-01246-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zwolińska, Weronika Dmitrzak-Węglarz, Monika Słopień, Agnieszka Biomarkers in Child and Adolescent Depression |
title | Biomarkers in Child and Adolescent Depression |
title_full | Biomarkers in Child and Adolescent Depression |
title_fullStr | Biomarkers in Child and Adolescent Depression |
title_full_unstemmed | Biomarkers in Child and Adolescent Depression |
title_short | Biomarkers in Child and Adolescent Depression |
title_sort | biomarkers in child and adolescent depression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867683/ https://www.ncbi.nlm.nih.gov/pubmed/34590201 http://dx.doi.org/10.1007/s10578-021-01246-y |
work_keys_str_mv | AT zwolinskaweronika biomarkersinchildandadolescentdepression AT dmitrzakweglarzmonika biomarkersinchildandadolescentdepression AT słopienagnieszka biomarkersinchildandadolescentdepression |