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Biomarkers in Child and Adolescent Depression

Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the p...

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Autores principales: Zwolińska, Weronika, Dmitrzak-Węglarz, Monika, Słopień, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867683/
https://www.ncbi.nlm.nih.gov/pubmed/34590201
http://dx.doi.org/10.1007/s10578-021-01246-y
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author Zwolińska, Weronika
Dmitrzak-Węglarz, Monika
Słopień, Agnieszka
author_facet Zwolińska, Weronika
Dmitrzak-Węglarz, Monika
Słopień, Agnieszka
author_sort Zwolińska, Weronika
collection PubMed
description Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future directions in the research on this subject. More studies on depression involving the youth population seem vital to comprehend the natural course of the disease and identify features that may underlie commonly observed differences in treatment outcomes between adults and children.
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spelling pubmed-98676832023-01-23 Biomarkers in Child and Adolescent Depression Zwolińska, Weronika Dmitrzak-Węglarz, Monika Słopień, Agnieszka Child Psychiatry Hum Dev Article Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future directions in the research on this subject. More studies on depression involving the youth population seem vital to comprehend the natural course of the disease and identify features that may underlie commonly observed differences in treatment outcomes between adults and children. Springer US 2021-09-29 2023 /pmc/articles/PMC9867683/ /pubmed/34590201 http://dx.doi.org/10.1007/s10578-021-01246-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zwolińska, Weronika
Dmitrzak-Węglarz, Monika
Słopień, Agnieszka
Biomarkers in Child and Adolescent Depression
title Biomarkers in Child and Adolescent Depression
title_full Biomarkers in Child and Adolescent Depression
title_fullStr Biomarkers in Child and Adolescent Depression
title_full_unstemmed Biomarkers in Child and Adolescent Depression
title_short Biomarkers in Child and Adolescent Depression
title_sort biomarkers in child and adolescent depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867683/
https://www.ncbi.nlm.nih.gov/pubmed/34590201
http://dx.doi.org/10.1007/s10578-021-01246-y
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