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Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice
The tubulinopathies are an umbrella of rare diseases that result from mutations in tubulin genes and are frequently characterised by severe brain malformations. The characteristics of a given disease reflect the expression pattern of the transcript, the function of a given tubulin gene, and the role...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867703/ https://www.ncbi.nlm.nih.gov/pubmed/36681692 http://dx.doi.org/10.1038/s41598-023-27782-2 |