Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Aberrant Wnt activation has been reported in failing cardiomyocytes. Here we present single cell transcriptome profiling of hearts with inducible cardiomyocyte-specific Wnt activation (β-cat(Δex3)) as well as with compensatory and failing hypertrophic remodeling. We show that functional enrichment a...

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Detalles Bibliográficos
Autores principales: Schoger, Eric, Bleckwedel, Federico, Germena, Giulia, Rocha, Cheila, Tucholla, Petra, Sobitov, Izzatullo, Möbius, Wiebke, Sitte, Maren, Lenz, Christof, Samak, Mostafa, Hinkel, Rabea, Varga, Zoltán V., Giricz, Zoltán, Salinas, Gabriela, Gross, Julia C., Zelarayán, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867722/
https://www.ncbi.nlm.nih.gov/pubmed/36681760
http://dx.doi.org/10.1038/s42003-022-04402-9

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