Inhibition of carnitine palmitoyl-transferase 1 is a potential target in a mouse model of Parkinson’s disease

Glucose metabolism is dysregulated in Parkinson’s disease (PD) causing a shift toward the metabolism of lipids. Carnitine palmitoyl-transferase 1A (CPT1A) regulates the key step in the metabolism of long-chain fatty acids. The aim of this study is to evaluate the effect of downregulating CPT1, eithe...

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Detalles Bibliográficos
Autores principales: Trabjerg, Michael Sloth, Andersen, Dennis Christian, Huntjens, Pam, Mørk, Kasper, Warming, Nikolaj, Kullab, Ulla Bismark, Skjønnemand, Marie-Louise Nibelius, Oklinski, Michal Krystian, Oklinski, Kirsten Egelund, Bolther, Luise, Kroese, Lona J., Pritchard, Colin E. J., Huijbers, Ivo J., Corthals, Angelique, Søndergaard, Mads Toft, Kjeldal, Henrik Bech, Pedersen, Cecilie Fjord Morre, Nieland, John Dirk Vestergaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867753/
https://www.ncbi.nlm.nih.gov/pubmed/36681683
http://dx.doi.org/10.1038/s41531-023-00450-y

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