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Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation

Patients with mutations of WDR4, a substrate adaptor of the CUL4 E3 ligase complex, develop cerebellar atrophy and gait phenotypes. However, the underlying mechanisms remain unexplored. Here, we identify a crucial role of Wdr4 in cerebellar development. Wdr4 deficiency in granule neuron progenitors...

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Detalles Bibliográficos
Autores principales:	Wu, Pei-Rung, Chiang, Shang-Yin, Midence, Robert, Kao, Wen-Chao, Lai, Chun-Lun, Cheng, I-Cheng, Chou, Shen-Ju, Chen, Chih-Cheng, Huang, Chih-Yang, Chen, Ruey-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867761/ https://www.ncbi.nlm.nih.gov/pubmed/36681682 http://dx.doi.org/10.1038/s41419-022-05442-z

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