Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I

Parthanatos is one of the major pathways of programmed cell death in ischemic stroke characterized by DNA damage, poly (ADP-ribose) polymerases (PARP) activation, and poly (ADP-ribose) (PAR) formation. Here we demonstrate that crocetin, a natural potent antioxidant compound from Crocus sativus, anta...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Li, Ying, Zhang, Qian, Wang, Hanxun, Xiu, Wenyu, Xu, Pu, Deng, Yujie, Huang, Wanxu, Wang, Dan Ohtan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867762/
https://www.ncbi.nlm.nih.gov/pubmed/36681688
http://dx.doi.org/10.1038/s41419-023-05581-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867762/
https://www.ncbi.nlm.nih.gov/pubmed/36681688
http://dx.doi.org/10.1038/s41419-023-05581-x

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