Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and β-halohydrins

Asymmetric reduction of prochiral ketones, particularly, reductive desymmetrization of 2,2-disubstituted prochiral 1,3-cyclodiketones to produce enantiopure chiral alcohols is challenging. Herein, an anthrol reductase CbAR with the ability to accommodate diverse bulky substrates, like emodin, for as...

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Detalles Bibliográficos
Autores principales: Hou, Xiaodong, Xu, Huibin, Yuan, Zhenbo, Deng, Zhiwei, Fu, Kai, Gao, Yue, Liu, Changmei, Zhang, Yan, Rao, Yijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867772/
https://www.ncbi.nlm.nih.gov/pubmed/36681664
http://dx.doi.org/10.1038/s41467-023-36064-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867772/
https://www.ncbi.nlm.nih.gov/pubmed/36681664
http://dx.doi.org/10.1038/s41467-023-36064-4

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